Correlation Analysis Between Risk Factors In Patients With Postmenopausal Osteoporotic Fratures

ObjectiveTo explore the risk factors and correlation analysis of osteoporotic fractures in postmenopausal women,and provide prevention and treatment strategies for this population,strengthen monitoring and intervention of high-risk factors,and reduce the incidence of fractures.MethodsA retrospective study design was used to investigate the factors influencing postmenopausal osteoporotic fractures in patients diagnosed with osteoporosis who underwent bone density testing at Guangzhou Medical University Affiliated Third Hospital from January 2020 to December 2022.Relevant factors,including age,height,weight,body mass index(BMI),L1-4 bone mineral density(BMD),femoral neck BMD,total hip BMD,diabetes status,chronic liver and kidney disease status,cardiovascular disease status,early menopause,history of fractures,use of sleeping pills,use of antidepressants,use of glucocorticoids,frequency of falls,exercise habits,smoking status,alcohol consumption,education level(college degree or above),and family history of fractures or osteoporosis,were collected.One-way regression analysis and chi-square test were used to screen out influential factors for continuous independent variables and categorical independent variables,respectively,and then statistically significant variables were included in the binary logistic regression analysis.ResultsA total of 520 postmenopausal patients with osteoporosis were investigated in this study,of whom 260 had osteoporotic fractures and 260 had no osteoporotic fractures.The mean age of the fracture group was 69.83 ± 8.45 years,which was significantly higher(P < 0.05)than that of the non-fracture group(64.95 ± 7.83years);the mean height of the fracture group was 152.56 ± 6.62 cm,which was lower(P < 0.05)than that of the non-fracture group(154.66 ± 6.33cm);the mean weight of the fracture group was55.65 ± 8.49 kg,which was higher(P < 0.05)than that of the non-fracture group year(57.43±8.44kg)was reduced(P<0.05).In univariate analysis of the fracture and nonfracture groups,age,height,weight,L1-4 BMD,femoral neck BMD,total hip BMD,comorbid cardiovascular disease,history of falls,history of fractures,exercise habits,early menopause,smoking,alcohol consumption,education level of college or higher,osteoporosis in first-degree relatives,and history of fractures in first-degree relatives were associated with the occurrence of osteoporotic fractures in postmenopausal women showed correlations,and further included in the binary logistic regression analysis,age(OR=2.039,95% CI 2.009-2.070),height(OR=1.046,95% CI 1.010-1.083),L1-4 BMD(OR=1.091,95% CI 1.029-1.156),total hip BMD(OR=1.067,95%CI 1.021-1.114,femoral neck BMD(OR=1.078,95%CI 1.026-1.131),frequent falls(OR=3.308,95%CI 2.037-5.372),history of fracture(OR=2.216,95%CI 1.362-3.604),exercise habit(OR =0.529,95%CI 0.056-0.910),early menopause(OR=7.525,95%CI 4.642-12.198),and first-degree relative with osteoporosis(OR=2.016,95%CI1.066-3.816)were significantly associated.ConclusionAdvanced age,low height,low BMD,history of frequent falls,history of fractures,early menopause,and history of osteoporosis in first-degree relatives are risk factors for osteoporotic fractures in postmenopausal women,and an exercise habit of more than30 minutes per day and 150 minutes per week may reduce the risk of osteoporotic fractures in postmenopausal women.