Analysis On Risk Factors Of Postmenopausal Osteoporosis In Tibetan And Han Women Among Physical Examination In A Hospital

ObjectiveIn order to solve the difference of postmenopausal osteoporosis(PMOP)between Tibetan and Han women,improve the health level of postmenopausal women in highaltitude minority areas and prevent the occurrence of PMOP,this study retrospectively analyzed the risk factors of PMOP in Tibetan and Han women in the physical examination population of the Affiliated Hospital of Qinghai University,to provide reference basis for clinical prevention and treatment of PMOP.MethodsThis study adopted the research of a single-center retrospective case-control,selecting 320 female patients who underwent physical examination in the Affiliated Hospital of Qinghai university from Feb.2016 to Jun.2020 with a minimum age of 1 year as subjects(case accumulation,until the sample size requirements were met),a total of 160 women with osteoporosis were included in the osteoporosis groups,80 in Tibetan and Han nationality respectively.160 women with PMOP were included in the PMOP group,80 in Tibetan and Han nationality(respectively);160 women with normal bone mineral density were included in the control group,80 in Tibetan and Han nationality.In order to ensure the comparability of patients in diferent groups,the propensity score matching method was used to determine the source of study sample,and the matching ratio was 1:1,and the redundant objects were discarded.Data were collected by questionnaire,physical examination,and laboratory tests,including bone mineral density,serum 25-(OH)-(OH)D3、BGP、Ca、P expression level,age,nationality,past medical history,surgical history,trauma history,clinical treatment,menopause time,menopause years,height and weight,exercise mode and time,and dietary preference were statistically analyzed for the risk factors of postmenopausal osteoporosis in Tibetan and Han women.Results1.Comparsion between two groups shows no significant difference in age and menopausal age(P=0.350),BGP the meaningful for statistic(P=0.005),menopausal years,bone mineral density 25-(OH)D3(nmol/L)、P is significantly different(P<0.001).2.The bone mineral density of different parts of women decreases with the increase of menopause years.The bone mineral density of lumbar L1 is the lowest,L3 is the highest,and that of hip Ward area is the lowest.The bone mineral density of Inter Tro was the highest,the bone mineral density of 1/3 of fore arm was the highest,and that of Ultra was the lowest.3.The duration of menopause in osteoporosis group were significantly higher than control group,and the bone mineral density was significantly lower than control group,with statistical significance(P<0.05).4.The bone mineral density of 50-54 years was compared with the other age groups with PMOP,and the difference was statistically significant(P<0.05).The bone mineral density of PMOP group of Han and Tibetan decreased gradually with the increase of menopausal age,while the decrease rate of bone mineral density of PMOP group of Tibetan was slower than nationality Han.The bone mineral density of Tibetan postmenopausal osteoporosis group was significantly higher than Han.5.Among 320 subjects,156 were exercisers of which 87 were Han,covering 5 5.77%,69 were Tibetan,covering 44.23%;164 were non-exerciser,of which 73 were Han,covering 44.51%,Tibetan 91,covering 55.49%,there is no statistical difference(P>0.05)。But with the increasement of years and weeks of exercise,bone mineral density has a certain trend of increasing,and the difference was significant(P<0.05).6.The height,weight and body mass index of the control group in the same nationality group were higher than those of the PMOP group,the differences were statistically significant(P<0.05),there was significant positive correlation between bone mineral density and height,weight and BMI in different nationality groups(P<0.01).Among them Han was higher correlation than Tibetan in bone mineral density,weight and BMI of postmenopausal osteoporosis group.7.Among the 320 subjects,16 were underweight,covering 5.00%,normal weight 131 covering 40.94%,overweight 92,covering 28.75%,obese 8,covering 25.31%.In the PMOP group of Han and Tibetan,the BMI increased with the occurrence of obesity,and the growth trend of the two nationality groups was consistent.8.Low age,low weight and high BGP were protective factors of PMOP(P<0.05),while long postmenopausal duration and low25-(OH)D3were independent risk factors of PMOP in Han and Tibetan populations(P<0.05).ConclusionThere was a negative correlation between the postmenopausal duration and bone mineral density.The decrease of bone mineral density of postmenopausal in Tibetan women was lower than Han,and the menopause was older and lower by 25-(OH)D3,low BGP is a risk factor for PMOP in Han and Tibetan,while low age and low weight are protective factors for PMOP and there is no difference between nationalities.