Correlation Between Preoperative Lymphocyte To Monocyte Ratio And Prognosis Of Laryngeal Cancer: A Meta-analysis

Objective:Meta-analysis was performed to explore the relationship between preoperative high and low expression of lymphocyte monocyte ratio(LMR)and prognosis-related indicators of laryngeal cancer patients after treatment,including age,T-stage,presence of lymph node metastasis,clinical stage,degree of differentiation,site of origin,overall survival,progression-free survival,disease-free survival,recurrence-free survival,and cancer-specific survival,in order to predict clinical prognosis of laryngeal cancer patients provide evidence-based medical support.Methods:A literature search was conducted on China Knowledge Network,Wanfang database,Vipshop database,China Biomedical Literature Service,Pubmed,cochrane library,Embase,and Web of Science to collect literature on LMR related to prognosis of laryngeal cancer up to March 2023,without restricting the type of study.The quality of the literature was evaluated using the NOS scale and QUIPS prognostic scale,and Meta-analysis was performed using Revman 5.4 and STATA 12.0 software,and the inclusion indicators were the number of LMR in high and low expression groups associated with each clinicopathological feature of the disease,the risk ratio(HR)associated with survival data and its 95% confidence interval(95% CI),and the outcome indicators including overall survival,progression-free progression survival,disease-free survival,recurrence-free survival,and cancer-specific survival.Results:The results of the analysis suggested that the preoperative LMR expression level was correlated with T stage,clinical stage,presence of lymph node metastasis,and pathological differentiation,and patients with high preoperative LMR expression had better T stage,clinical stage,presence of lymph node metastasis,and pathological differentiation;however,the preoperative LMR expression level was not correlated with age and site of disease.However,the preoperative LMR expression level was not correlated with age and site of disease.Preoperative LMR expression was not associated with overall survival(P>0.05),and the heterogeneity was significant(I2=82%,P<0.00001),and according to the subgroup analysis by inclusion effect size ratio,the preoperative LMR expression level was associated with overall survival after treatment in laryngeal cancer patients(P<0.00001,I2=0),and the overall survival of patients with high preoperative LMR expression was better than that of the low expression group,and the overall survival The main source of heterogeneity in the group was the inclusion of the effect size ratio approach;in progression-free survival,preoperative LMR expression level was not associated with patients’ progression-free survival(P>0.05);in disease-free survival,preoperative LMR expression level was associated with DFS,and high expression of LMR predicted better disease-free survival;in recurrence-free survival,the difference between preoperative LMR expression level and patients’ recurrence-free survival was not statistically significant(P>0.05)In cancer-specific survival,preoperative LMR expression levels correlated with patients’ cancer-specific survival,and higher expression of LMR predicted better prognosis.Conclusion:In this study,we found that preoperative LMR expression correlated with T-stage,clinical stage,presence or absence of lymph node metastasis,degree of pathological differentiation,overall survival,disease-free survival,and cancer-specific survival in laryngeal cancer patients by Meta-analysis,and high expression of LMR predicted better T-stage,clinical stage,presence or absence of lymph node metastasis,degree of pathological differentiation,overall survival,disease-free survival,and cancer-specific survival;however,it was not correlated with Age,site of origin,progression-free survival,and recurrence-free survival were not related,so it is meaningful to use preoperative LMR to predict the prognosis of laryngeal cancer patients,especially when overall survival is used as the survival evaluation index.