Preoperative Neutrophil-lymphocyte Ratio And Lymphocy Te-monocyte Ratio Predict The Prognosis Of Patients With Non-muscle Invasive Bladder Cancer

Objective:To explore the value of preoperative neutrophil-lymphocyte ratio(NLR)and lymphocyte-monocyte ratio(LMR)in predicting the prognosis of patients with non-muscle invasive bladder cancer(NMIBC).Methods:Clinical data of NMIBC patients treated with transurethral resection of bladder tumor(TURBT)were retrospectively analyzed.According to the preoperative NLR and LMR,the patients were divided into 4 groups: low NLR group(<2.4,n=172),high NLR group(≥2.4,n=98),low LMR group(<4,n=98)and high LMR group(≥4,n=172).The recurrence-free survival curves were made with Kaplan-Meier method,and compared with log-rank test.The independent risk factors influencing the prognosis of patients were analyzed with Cox multivariate analysis.Results:NLR was related to tumor number,pathological grade,T stage,recurrence and progression(P<0.05).LMR was related to gender and age.The results of univariate analysis indicated that NLR,tumor number,tumor size,pathological grade and T stage were related to the non-recurrence survival(P<0.05).Multivariate analysis indicated that NLR,tumor number,pathological grade and T stage were the factors influencing tumor recurrence.Conclusion:Preoperative NLR is an independent risk factor influencing postoperative recurrence-free survival of NMIBC patients,which can be used as a prognostic indicator.Patients with high NLR has higher recurrence rate than patients with low NLR.