| Objective:1.To confirm the clinical efficacy and safety of Yiqi Jianpi method combined with heat sensitive moxibustion in the treatment of skin type allergic purpura of qi failing to control blood;2.To explore the effect of Yiqi Jianpi method combined with heat sensitive moxibustion on the recurrence rate and T lymphocyte subsets(CD4~+,CD8~+,CD4~+/CD8~+)of skin type allergic purpura of qi failing to control blood.Method:The subjects of the study were chosen strictly on the basis of diagnostic criteria,and the 70 eligible patients were numbered by visit time,and then divided into three groups by the random number method of Excel.Of these,23 patients were assigned to each group A and B,and24 patients were assigned to the combined group.Control group A was given Yiqi Jianpi decoction orally,twice a day;In the control group B,heat sensitive moxibustion was given once a day.The patients in the combined group were treated with Yiqi Jianpi decoction combined with heat sensitive moxibustion.The treatment period of all 3 groups was 8 weeks.Before treatment,4 weeks after treatment and 8 weeks after treatment were selected as the observation time points,the patients were instructed to fill in the TCM syndrome score table at three time points,and 15 healthy people were selected as controls.Meanwhile,the level of T lymphocyte subsets(CD4~+,CD8~+,CD4~+/CD8~+)of in healthy people and patients before and after treatment was measured,and the data were statistically analyzed.If any adverse reactions occurred during the treatment,corresponding treatment should be carried out according to its severity.One month after the end of treatment,the patients were followed up to record their recurrence in detail,and finally the collected data were statistically analyzed.Results:1.Baseline comparison:A total of 70 patients were collected in this study.Due to shedding or elimination during the study,66 patients were finally included,including 21 cases in control group A and B,and24 cases in combination group.All cases met the inclusion criteria.The data of gender,age and course of disease in the three groups were not statistically significant after comparison(P>0.05),and the children in the three groups were comparable in gender,age and course of disease.2.Before treatment,the main symptoms(rash distribution,density,color,size),minor symptoms(facial discomfort,eating less and nanosight,body drowsiness and fatigue,dizziness and palpitations,and loose stools),total scores of primary and secondary symptoms,and T lymphocyte subsets(CD4~+,CD8~+,and CD4~+/CD8~+)were not statistically significant(P>0.05)and comparable between the three groups.3.Comparison of main symptom scores:after each course of treatment,the main symptom scores of the three groups were lower than those of the previous course(P<0.05).After 4 and 8 weeks of treatment,the reduction of the main symptom score in the combined group was better than that in the control group A and B(P<0.05),and there was no difference between the control group A and the control group B(P>0.05).4.Comparison of secondary symptom scores:at the end of each course of treatment,the secondary symptom scores of the three groups were lower than those of the previous course(P<0.05);After 4 and 8 weeks of treatment,the reduction of sub-symptom scores in the combined group was better than that in the control group A and B(P<0.05),and there was no difference between the control group A and the control group B(P>0.05).5.Comparison of total scores of primary and secondary symptoms:after each course of treatment,the total scores of primary and secondary symptoms in the three groups were lower than those in the previous course of treatment(P<0.05).After 4 and 8 weeks of treatment,the total scores of primary and secondary symptoms in the combined group were better than those in the control group A and B(P<0.05),and there was no difference between the control group A and the control group B(P>0.05).6.Curative effect comparison:after 8 weeks treatment,joint group effective rate was 91.7%,and the effectiveness of the control group A and B were 76.2%and 61.9%respectively.Combined treatment group is better than that of control group A and B(P<0.05),the control group there was no difference in the curative effect comparison between A and B(P>0.05).7.T lymphocyte subset contrast:three groups after treatment the level of T lymphocyte subsets(CD4~+,CD8~+,CD4~+/CD8~+)was improved(P<0.05),but the joint group improve ability is better than that of control group A and B(P<0.05),control group A and B have no difference(P>0.05).8.Recurrence rate contrast:the recurrence rate was 43.8%in control group A,46.2%in control group B,and 9.5%in the combination group.The recurrence rate of the combined group was obviously superior to that of A and B group.9.Safety aspects:control group B,combination group had 1 minor adverse reaction each during treatment,which did not affect the results of the study.Conclusions:1.Yiqi Jianpi method combined with heat sensitive moxibustion for the exact purpose of treating skin type allergic purpura of qi failing to control blood has positive clinical effect and high safety,which is worthy of clinical promotion.2.Yiqi Jianpi method combined with heat sensitive moxibustion can expressively shorten the recurrence rate and improve the quality of life of patients with skin type allergic purpura of qi failing to control blood.3.Yiqi Jianpi method combined with heat sensitive moxibustion can regulate the levels of T lymphocyte subsets(CD4~+,CD8~+,CD4~+/CD8~+)and regulate the body’s immune function in patients with skin type allergic purpura of qi failing to control blood.4.Yiqi Jianpi method combined with heat sensitive moxibustion is superior to Yiqi Jianpi method alone or heat sensitive moxibustion in the treatment of skin type allergic purpura of qi failing to control blood,reducing the recurrence rate and regulating the level of T lymphocyte subsets(CD4~+,CD8~+,CD4~+/CD8~+). |
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