Clinical Observation Of Self-made Kuanxiong Jieyu Prescription On Chronic Heart Disease Combined With Anxiety State (Qi Stagnation And Phlegm Stasis Syndrome)

Objective: To observe the clinical efficacy and safety of the self-made Kuanxiong Jieyu prescription in the treatment of coronary heart disease paired with anxiety state,and establishing a solid evidence-based foundation for future clinical practice.Methods: Patients with stable angina pectoris combined with anxiety were selected from outpatients and inpatients of The First Clinical Hospital of Jilin Academy of Chinese Medicine,and 72 patients who met the inclusion criteria were divided into control and treatment groups by randomized grouping.36 patients in the control group received basic Western medicine treatment and Delixin,while 36 patients in the treatment group received basic Western medicine treatment and self-developed formula for relieving depression in the chest.Results: In the treatment group and the control group,respectively,4 cases and 3 cases were lost over the course of therapy,resulting in a final case count of 32 cases in the treatment group and 33 cases in the control group.1.After 28 days of therapy,the two groups were compared,and it was found that the treatment group’s angina pectoris and Traditional Chinese Medicine symptom total effective rates were higher than those in the control group,p<0.05,and the points of angina pectoris and Traditional Chinese Medicine symptoms in both groups after treatment were lower than those before treatment,p<0.05,indicating that the regimen in the treatment group was more effective in relieving angina pectoris symptoms and improving Traditional Chinese Medicine symptoms compared with that in the control group;2.In terms of electrocardiogram efficacy and In the comparison of electrocardiographic efficacy and nitroglycerin withdrawal rate,it was found that the total efficiency of electrocardiographic and nitroglycerin withdrawal rate in the treatment group were slightly better than those in the control group,but there was no significant difference,p>0.05,indicating that the improvement of electrocardiographic and nitroglycerin withdrawal rate in the two groups after treatment was not significant;3.In the intra-group comparison,the Hamilton Anxiety Scale scores decreased in both groups after treatment compared to the pre-treatment scores.In the inter-group comparison,the overall efficiency of Hamilton Anxiety Scale scores was higher in the treatment group than in the control group,p<0.05,indicating that both regimens could alleviate the anxiety state,but the treatment group could significantly improve the patients’ anxiety state more than the control group.Conclusion:1.The self-made Kuanxiong Jieyu prescription can effectively alleviate the symptoms of angina pectoris in coronary heart disease with Qi stagnation and phlegm stasis combined with anxiety state,reduce the number and duration of angina attacks,reduce nitroglycerin dosage and improve electrocardiographic changes.2.The self-made Kuanxiong Jieyu prescription can effectively improve the TCM symptoms and reduce the TCM symptom score of coronary heart disease with Qi stagnation and phlegm stasis combined with anxiety state.3.The self-made Kuanxiong Jieyu prescription can reduce HAMA scores and effectively relieve anxiety in coronary heart disease with Qi stagnation and phlegm stasis syndrome.