Clinical Study On The Treatment Of Obese Pre-diabetes With Damp-heat Retention Spleen From "Xuanfu-Piluo-Sangao" Pathway

Objective: This study is guided by the academic thought of the tutor “ Xiefu Sangao ”,and starts from the“ Xuanfu-Piluo-Sangao ” Pathway to treat obese pre-diabetes(IGT)patients.By observing the changes of TCM symptoms and physical and chemical indexes before and after treatment in the treatment group and the control group,the effectiveness and safety of traditional Chinese medicine treatment were objectively evaluated,aiming to open up new ideas and new methods for early intervention and reversal of obese pre-diabetes(IGT).Methods: 72 patients who met the inclusion criteria of this trial were given random numbers by the random number table method according to the order of consultation,while the numbers were then sorted by size,with the first 36 being the treatment group and the last36 being the control group.The control group was treated with basic treatment combined with Acarbose Capsules,and the treatment group was treated with basic treatment combined with traditional Chinese medicine decoction.4 weeks was a course of treatment,and 3 courses of continuous observation were observed for 12 weeks.The differences of TCM syndrome scores,fasting blood glucose(FPG),2-hour postprandial blood glucose(2h PG),glycosylated hemoglobin(Hb A1c),body mass index(BMI),waist circumference(WC),waist-to-hip ratio(WHR),blood lipids index(CHO,TG,LDL-C,HDL-C),fasting serum insulin(INS),insulin resistance index(HOMA-IR),and the safety indicators such as the routine test of blood and urine,liver and kidney function,electrocardiogram were observed before and after treatment.Results: After treatment,the treatment group and the control group had a certain effect in improving obesity-related indicators,glucose and lipid metabolism and insulin resistance levels compared with before treatment(P < 0.05).The treatment group was better than the control group in improving TCM symptoms(P < 0.05).The treatment group was superior to the control group in improving the level of glucose metabolism(FPG,2h PG,Hb A1c),BMI,WC,WHR,INS,HOMA-IR and TG(P < 0.05).Conclusion: The results of the study showed that based on the theory of“ Xiefu Sangao ”,starting from the “ Xuanfu-Piluo-Sangao ” Pathway,Jianpi Yiqi and Guhu Sangao were used to treat the root cause,Kaixuan Tongluo and Qingre Qushi were used to treat the symptoms,the specimens were treated together,and the latent pathogens were given a way out.The use of traditional Chinese medicine decoction in the treatment of obese prediabetes(IGT)can significantly improve the clinical symptoms of patients,and the body weight has a downward trend.It can effectively improve the patient ’s glucose and lipid metabolism level and insulin resistance level,and has a certain effect on the redistribution of abdominal visceral adipose tissue.No obvious discomfort symptoms and safety problems were found during the treatment,which was worthy of further promotion and application.