| Objective: To discover the new traditional Chinese medicine that can potently treat impaired glucose tolerance (IGT), instead of Rosiglitazone, through observing the clinical effect of treatment in IGT, which is main of using Xiao Ke An Capsule.Methods: Eighty cases, corresponded to diagnosis standard on IGT of WHO(1999),were randomly divided into a treatment group(n=42) and a control group (n=38) in terms with the date patients were hospitalized which is odd or even .Basic treatment :the patients of two groups were all given propaganda and education about IGT to wake up to the bad outcome of IGT development, then were glad to accept and initiatively cooperate in survey on diet structure ,take more healthy exercises, keep fit build ,prevent obesity; get on a severe diet :figure up the total caloric required daily according to the standard height and sport quantity ; healthy sport intervention : add 1-2 sport units to the normal sport quantity daily, or take exercises at least a half hour daily 3 days weekly, and hold to that long .Based on that basal treatment, treated group: Xiao Ke An Capsule (produced by the manufacturing laboratory of our hospital, composed of stir-baked Bupleurum Chinese with vinegar 15g, Radix Paeoniae Alba 15g,angelicae radix 15g, hoelen 30g , atractylodes macrocephala 15g, prepared Radix Glycyrrhizae 12g, coptis chinensis 12g, filed mint 9g, litchi semen 15g, dry bitter melon power 30g, atracty lodes rhizome 15g, figwort root 15g, milkvetch root 30g, Chinese yam 20g, rehmannia dride rhizome 15g, Cortex Moutan 12g, all of them were gritted into powder, sieve with 100 mu luo, then filled into capsules, each capsule weight 0.3g) was given orally in a dose of 6 grains three times daily; control group: Rosiglitazone Tablet was given orally in a dose of 4mg once a day. All for six months, and be visited for a long time. Before and after the treatment, fasting plasma glucose(FPG), two-hour postprandial plasma (2hPG) glucose, fasting insulin (FINS), two-hour postprandial insulin(2hINS), fasting C-peptide(FCP) andtwo-hour postprandial C-peptide(2hCP) would be determined in the two groups. Their changes would be surveyed, then be dealed with statistic test of average. Observe the poisonous and side effect of the medicine.Result: The effective rate in the treated group was 83% with the in effectual rate 17%; and as for the control group with efficiency 89% and in efficiency 11%. The patients in two groups over all tested on FPG, 2hPG, FINS, 2hINS, FCP and 2hCP before and after the treatments. Dealed with the average (x±s) of the outcomes in and between the two groups by the statistic test, and discovered that the differences between the effects before and after the treatment in the two groups(P<0.01). The effect of treated group as comparable with that of control group (P>0.05).No obvious poisonous and side effect took place during and after the treatments in two groups.Conclusion: The pathogenesis of IGT is liver depression and spleen deficiency, qi deficiency arid yin deficiency, and blood stasis combined with heat. Xiao Ke An Capsule could stretch the liver invigorate the spleen, eliminating heat by nourishing yin, promoting qi to activate blood, reducing resistance to insulin, bettering insulin sensitivity, so as to cure IGT. It has less adverse reaction, favorable safety, and the same significant clinical effect as Rosiglitazone Tablet. Compared them with each other, there's no significant difference between them. They could prevent Type2 diabetes mellitus, are worthy to' be generalized in clinical application. |
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