Treatment Based On ’Dispelling Tonifying Homology’ Clinical Study On Simple Obesity Combined With Dyslipidemia

Objective: To investigate the clinical efficacy and safety of ’ Xiaobu Tongtiao Prescription ’combined with lifestyle intervention in the treatment of simple obesity complicated with dyslipidemia(spleen-deficient phlegm-dampness),and to analyze the effect of this prescription on chinese medicine syndromes,weight,waist circumference,body mass index(BMI),hip circumference,waist-hip ratio(WHR),blood lipid level and other factors in patients with simple obesity complicated with dyslipidemia of spleen deficiency and phlegm dampness syndrome,and to further regulate the advantages and significance of simple obesity complicated with dyslipidemia.Methods: From November 2021 to October 2022,72 patients with simple obesity and dyslipidemia were selected from the outpatient department of endocrine and metabolic diseases and the health management center of preventive treatment of disease in the affiliated hospital of changchun university of traditional Chinese medicine.According to the random number table method,72 patients with spleen deficiency and phlegm dampness syndrome and simple obesity and dyslipidemia in the diagnosis of western medicine were divided into therapeutic group and matched group,with 36 cases in each group.The control group was treated with lifestyle intervention,while the treatment group was treated with ’Xiaobu Tongtiao Decoction ’,one dose per day,for 12 weeks.The body height stature,weight,commerbund,hipline and splasma lipid levels of the two groups before and after treatment were measured respectively.The changes of TCM syndrome scores and total scores of TCM syndromes in the two groups were recorded and compared.The electrocardiogram,liver and kidney multi-function,blood routine examination and urine routine examination before and after treatment were detected to evaluate the clinical efficacy and safety of ’ Xiaobu Tongtiao Decoction ’ in the treatment of simple obesity with dyslipidemia.Results: A total of 61 subjects accomplished the test,including 30 cases in the therapeutic group and 31 cases in the control group,and 9 cases fell off.The results of the experiment are as follows.1.The general effective rate of the therapeutic group was 83.33 %,which was significantly better than that of the contrast group(48.39 %),and the difference was science of statistics significant(P < 0.05).Comparing the curative effect of TCM symptoms such as obesity,abdominal enlargement and fatigue,the two groups were improved,and the discrepancy was science of statistics significant(P < 0.05).2.Comparison within the group,the somatic weight,BMI,lumbar periphery,hipline,WHR,TCM symptom score and total TCM symptom score of the two groups before and after treatment were significantly lower than those before treatment,and the difference was science of statistics significant(P < 0.05).In other aspects,the therapeutic group was significantly better than the contrast group,and the difference was science of statistics significant(P < 0.05).3.In terms of triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)and other serum lipids levels,the therapeutic group and the control group were improved,but the treatment group was even more excellent the control group(P < 0.05).4.During the treatment process,no adverse reactions were found and no liver or kidney function damage was observed.Conclusion: The ’ Xiaobu Tongtiao Decoction ’ combined with diet and exercise and other lifestyles has a good clinical effect on the treatment of simple obesity with dyslipidemia and spleen deficiency and phlegm dampness syndrome patients.It can improve the blood lipid level,improve the clinical symptoms of patients and better reduce the total score of TCM symptoms.The total effect is better than simple lifestyle intervention.