Effect Of Jianpiqvshi Decoction Combined With Low-carbohydrate Diet On Simple Obesity Of Phlegm-dampness Type With Spleen Deficiency

ObjectiveTo observe the clinical effect of Jianpiqvshi decoction on simple obesity with spleen deficiency and phlegm dampness.MethodsA total of 90 cases of simple obesity with spleen deficiency and phlegm dampness were collected from patients admitted to the endocrinology department of foshan hospital of traditional Chinese medicine from September 2018 to April 2019 by the method of prospective randomized controlled clinical trial.The patients were randomly divided into control group and experimental group,with 45 cases in each group.Both groups were given low-carb diet as the routine basic treatment,and the experimental group received 1 dose of Jianpiqvshi decoction per day on this basis,with a course of treatment for 8 weeks.Changes of BMI,body fat rate,fasting blood glucose,blood fat,leptin and TCM syndrome score before and after treatment were observed.The data were analyzed to evaluate the effectiveness and safety of clearing damp prescription.Results1.There was no statistically significant difference between the experimental group and the control group in general data such as gender composition,age distribution,height,weight,BMI and body fat rate(P>0.05).Baseline balance between the two groups was comparable.2.At the 8th week of treatment,BMI and body fat were significantly lower in both groups(P<0.05),and BMI in the experimental group was significantly lower than those in the control group(P<0.05).After treatment,cholesterol in the two groups was significantly decreased(P<0.05),but there was no significant difference between the experimental group and the control group(P>0.05).There was no significant change in triglyceride,low density lipoprotein and high density lipoprotein in the two groups before and after treatment(P>0.05).After treatment,fasting blood glucose and leptin levels in both groups were significantly reduced(P<0.05),but there was no significant difference in fasting blood glucose and leptin levels between the experimental group and the control group(P>0.05).The TCM syndrome scores of both the control group and the treatment group were significantly reduced after the treatment(P<0.05),and the TCM syndrome scores of the experimental group were significantly lower than those of the control group(P<0.05).3.Compared with the clinical efficacy,the total effective rate of the control group was 51.1%;The total effective rate was 77.8%.The clinical efficacy of the experimental group was better than that of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions was lower in both groups,and there was no statistically significant difference between the two groups(P>0.05).ConclusionJianpiqvshi decoction has a good therapeutic effect on simple obesity of spleen deficiency phlegm dampness type,can effectively reduce weight and improve clinical syndromes of traditional Chinese medicine,and has a good safety and no obvious adverse reactions,which is worthy of clinical promotion.