A Meta-analysis Of Risk Factors For Idiopathic Central Precocious Puberty In Girls

Objective: To explore the risk factors of idiopathic precocious puberty through metaanalysis,and to provide the basis for the prevention of idiopathic precocious puberty.Methods: By searching the China National Knowledge Infrastructure,VIP Database,Wan fang Database,Chinese biological and medical database,Pub Med,Embase,the Cochrane library and Web of science databases,the Chinese and English literatures on the risk factors of ICPP published from January 2010 to November 2022 were collected.The types of studies could be divided into cohort study or case-control study,and the literatures were screened according to the inclusion and exclusion criteria.Rev Man5.4 software was used to analyze the final data.Results: At first,a total of 1482 related literatures were retrieved.After screening,9literatures were finally included,all of which were case-control studies.The final results of the meta-analysis were as follows: taking nutrition products regularly(OR=4.07,95%CI 3.20-5.18,P < 0.00001),using adult toiletries regularly(OR=3.71,95%CI 2.13-6.45,P<0.00001),the mother was treated with tocolysis during pregnancy(OR=3.37,95%CI 2.13-5.32,P<0.00001),eating hormonecontaining foods(OR=2.96,95%CI 2.02-4.33,P<0.00001),self-perceived heavy academic burden(OR=1.80,95%CI 1.04-3.09,P=0.03),eating fried food≥2 times per week(OR=1.98,95%CI 1.51-2.59,P<0.00001),sleeping with the light on(OR=2.20,95%CI 1.08-4.50,P=0.03),maternal age at menarche≤13 years old(OR3.84,95%CI 2.78-5.30,P < 0.00001),dietary imbalance(OR=3.50,95%CI 2.64-4.62,P < 0.00001)were risk factors of idiopathic precocious puberty in girls.Conclusion: Idiopathic precocious puberty is the most common type of precocious puberty in girls,and with the progress of the society,its incidence is increasing year by year.Therefore,it is of great significance to explore the risk factors of the disease,and then reduce or avoid exposure to these factors,so as to reduce its incidence.The results showed that taking nutrition products regularly,using adult toiletries regularly,the mother was treated with tocolysis during pregnancy,eating hormonecontaining foods,self-perceived heavy academic burden,eating fried food ≥ 2times per week,sleeping with the light on,maternal age at menarche≤ 13 years old,dietary imbalance were all risk factors of idiopathic precocious puberty in girls.