The Related Study Of Traditional Chinese Medicine Risk Factors For Disease In Girls With Idiopathic Central Precocious Puberty

Objective:A retrospective study of girls with Idiopathic Central Precocious Puberty (ICPP) of Chinese Medicine of the characteristics of its classification and distribution, analysis on risk factors, induced diseases and the correlation between them.Methods:The study is conducted in a retrospective method. The sample of the study is composed of the 92 confirmed cases of ICPP girls in Heilongjiang University of Chinese Medicine First Affiliated Hospital from April 2006 to April 2010. By observing its main syndrome, affiliated disease, and tongue pulse and etc.,the sample is further divided into four groups in accordance with the dialectical law of the Chinese medicine, they are, hyperactivity of fire due to yin deficiency group, the pathogenic fire derived from stagnation of liver-QI, spleen deficiency and intermingled phlegm group and other groups. We make a comparison on the regional distribution of different groups among the ICPP girls. In the meanwhile, we chose 45 healthy girls who came to our hospital to have physical examination, as the normal control group in our study. By means of questionnaire, we desire to explore the risky factors related with the disease, and the relationship between those risk factors and the syndrome of traditional Chinese medicine (TCM). A statistical analysis is made by the use of SPSS 17.0 software.Results:(1) TCM of ICPP syndromes can be divided into hyperactivity of fire due to yin deficiency group, the pathogenic fire derived from stagnation of liver-QI, spleen deficiency and intermingled phlegm group and other groups, the proportion of each group in the sample can listed in the following order, the pathogenic fire derived from stagnation of liver-QI > spleen deficiency and intermingled phlegm group> hyperactivity of fire due to yin deficiency. (2) Among all, there are six factors whose proportion (P<0.01or P<0.05)is significantly above the normal control group. They are, taking nutritional supplements, eating foods containing hormones, using skin care products for adults, tocolysis during the pregnancy, age of mother's menarche, and the exposure to emotional media. The proportional percentage of the other four types of factors was not significant enough (P> 0.05). (3) Logistic regression analysis showed that taking nutritional supplements, skin care products for adults, and eating food with hormones are closely related to ICPP (P<0.01or P<0.05) while other factors cannot be reflected in the equation. (4) analysis on the TCM of the high-risk factor showed that the age mother's menarche and tocolysis during pregnancy are the two factors that closely connected to hyperactivity of fire due to yin deficiency group (P<0.01or P<0.05), the favor for emotional media is closely related to the pathogenic fire derived from stagnation of liver-QI group (P<0.05); other three risk factors are related to various types of precocious puberty in children without significant difference (P> 0.05).Conclusion:The statistics in Harbin and the surrounding areas of ICPP girls are largely resulted from the pathogenic fire derived from stagnation of liver-QI while the from hyperactivity of fire due to yin deficiency in the southern cities. It can be explained by the difference on climatic conditions, physical factors and life style between the north and south. Out of the ten types of risk factors, six of them is closely related to precocious puberty, such as taking nutritional supplements, having food containing hormones and using skin care products for adults. They exerted a deep impact on different types of ICPP girls so that parents should pay more attention to it and make good and comprehensive precautions.