| Objective: To observe the clinical efficacy of the treatment of liver-depression and spleen-deficiency chronic prostatitis with modified Xiaoyao San and Tongxie Yaofang,and to provide reference for the clinical treatment of liver-depression and spleendeficiency chronic prostatitis in Chinese medicine.Method: In this study,according to the diagnostic criteria of traditional Chinese medicine and western medicine as well as the inclusion and exclusion criteria,72 cases of chronic prostatitis due to liver stagnation and spleen deficiency were selected and treated with modified Xiaoyao San and Tongxie Yaofang(Tianjiang Formula Granules)with one dose every day,three times a day.The patients were warmly taken after meals.During the treatment,wine,spicy and stimulating food were prohibited,and sedentary behavior was avoided.Four weeks constituted a course of treatment,and observation constituted one course of treatment.The changes and comparisons of NIH-CPSI score,TCM syndrome score,prostate examination score and Hamilton Anxiety and Depression Scale(HAMD)were observed before treatment and four weeks after treatment.The research data were analyzed using statistical methods,and the results were obtained and discussed.Result: A total of 72 cases were included in the study.One case was dropped out from the study,and the other one was excluded.The final effective case was 70 cases in total.1.70 patients with chronic prostatitis with hepatic depression and spleen deficiency were treated with modified Xiaoyao San and Tongxie Yaofang,According to the western medical efficacy criterion,that is,the improvement of NIH-CPSI total score,the results showed that the total effective rate was 90.00%,including 5 patients(7.14%),35 patients(50.00%)with obvious effect,23 patients(32.86%)in effective patients,and 7 patients(10.00%)in ineffective patients.According to the criteria for judging the efficacy of TCM symptoms,the results showed that the total effective rate reached 92.86%,including 6clinically controlled patients(8.57%),37 effective patients(52.86%),22 progressive patients(31.43%)and 5 ineffective patients(7.14%).2.Comparison of NIH-CPSI total points before and after treatment: the total NIH-CPSI points before treatment were 27.89±3.16,and the total NIH-CPSI points of 4 weeks of treatment were 11.96±4.67 after 4 weeks of treatment,and the total NIH-CPSI points after treatment were significantly reduced(P<0.01)after the two groups,proving that modified Xiaoyao San and Tongxie Yaofang can significantly improve the total NIH-CPSI points of patients with chronic prostatitis with liver depression and spleen deficiency.3.Comparison of the total points of TCM symptoms before and after treatment: the total points of TCM symptoms before treatment were 36.44±6.36,and the total points of TCM symptoms after 4 weeks of treatment were 12.97±7.40,compared with the two groups,the total points after treatment were significantly lower than the total points before treatment(P<0.01),proving that modified Xiaoyao San and Tongxie Yaofang can significantly improve the total points of TCM syndrome in patients with chronic prostatitis with liver depression and spleen deficiency.4.According to the comparison of TCM syndrome effects before and after treatment,the scores of frequent micturition and urgent urination were 6(6,6)and 0(0,3),respectively,showing a significant difference(P<0.01).The scores of incomplete urination or postdribbling urination before and after treatment were 6(6,6)and 0(0,3),respectively,and the differences were significant before and after treatment(P<0.01).The scores of occasionally turbid white at the end of urination or during defecation before and after treatment were 6(3,6)and 3(0,3),and the difference was significant(P<0.01).The symptom scores of falling swelling and dull pain in the sacrum of lower back,groin,lower abdomen and perineum before and after treatment were 6(3,6)and 3(0,3),showing significant difference(P<0.01).The symptom scores of impotence,premature ejaculation,spermatorrhea or ejaculatory pain before and after treatment were 6(3,6)and 0(0,3),respectively,and the difference was significant(P<0.01).The symptom scores of epigastric or hypochondriac distending pain were 2(2,2)and 0(0,1)before and after treatment,and the difference was significant before and after treatment(P<0.01).The scores of anorexia or loose stool uncomfortable before and after treatment were 2(1,2)and 0.5(0,1),respectively,and there was significant difference before and after treatment(P<0.01).The scores of loss of qi due to borborygmus were 2(0.75,2)and 0(0,1)before and after treatment,and the difference was significant before and after treatment(P<0.01).The abdominal pain was alleviated immediately before and after treatment,and the symptom reduction scores after reduction were 2(1,2)and 1(0,1),showing significant difference(P<0.01).The scores of chest stuffiness before and after treatment were 2(1,2)and 0(0,1),and the difference was significant(P<0.01).The scores of mental fatigue were 2(1,2)and 1(0,1)before and after treatment,and the difference was significant before and after treatment(P<0.01).The scores of good will,anxiety,depression or impatience before and after treatment were 2(1,2)and 1(0,1),respectively,and the differences were significant before and after treatment(P<0.01).It was proved that modified Xiaoyao San and Tongxie Yaofang could significantly improve the TCM syndrome scores of patients with chronic prostatitis of liver stagnation and spleen deficiency type.5.Comparison of total prostate points before and after treatment: the total points of prostate examination before treatment were 4(3,5),and the total points of prostate examination after 4 weeks of treatment were added and subtracted(Tianjiang formula granules)to 2(1,3),and the prostate examination points after 4 weeks of treatment were significantly lower than those before treatment(P<0.01),proving that modified Xiaoyao San and Tongxie Yaofang can significantly improve the total points of prostate examination in patients with chronic prostatitis with liver depression and spleen deficiency.6.The comparison of EPS WBC scores before and after treatment: The EPS WBC scores before and after treatment were 1(1,1),0(0,1),and the difference was significant(P<0.01).The small volume fraction of lecithin before and after treatment was 1(1,1),0.5(0,1),and the difference was significant(P<0.01).The prostate tenderness scores were 1(1,1)and 0(0,1)before and after treatment,and the difference was significant before and after treatment(P<0.01).The prostatic texture scores were 1(0,1)and 0(0,1)before and after treatment,and the difference was significant(P<0.01).It was proved that modified Xiaoyao San and Tongxie Yaofang could significantly improve the prostate examination scores of patients with chronic prostatitis of liver stagnation and spleen deficiency type.7.Comparison of Anxiety Scale scores before and after treatment;The score of Anxiety Scale before treatment was 23.43±4.26,and the score of Anxiety Scale was6.67±3.38 after 4 weeks of treatment,and the score of Hamilton Anxiety Scale was significantly lower than that before treatment(P<0.01)after 4 weeks of treatment,which proved that the addition and subtraction of Xiaoyao San and Tongxie Yaofang could significantly improve the Hamilton Anxiety Scale score in patients with chronic prostatitis with liver depression and spleen deficiency.8.Comparison of Depression Scale scores before and after treatment;The score of Depression Scale before treatment was 15(13,16.25),and the score of Depression Scale was 5(4,6.25)after 4 weeks of treatment,and the score of Hamilton Depression Scale after4 weeks of treatment was significantly lower than that before treatment(P<0.01),which proved that modified Xiaoyao San and Tongxie Yaofang could significantly improve the Hamilton Depression Scale score in patients with chronic prostatitis with liver depression and spleen deficiency.Conclusion: 1.The modified Xiaoyao San and Tongxie Yaofang can effectively improve the clinical symptoms of patients with chronic prostatitis with liver depression and spleen deficiency,which is mainly manifested in reducing NIH-CPSI scores,TCM syndrome points,Hamilton anxiety and depression scale scores,reducing the number of white blood cells in prostate fluid routine,increasing the number of lecithin bodies in prostate fluid routine,and alleviating prostate tenderness.2.The modified Xiaoyao San and Tongxie Yaofang had obvious curative effect on chronic prostatitis of liver stagnation and spleen deficiency type without obvious adverse reactions,which was worthy of clinical application. |
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