Clinical Observation On Anshen Dingxin Decoction In Treating Chronic Insomnia Of Deficiency Of Heart And Spleen

Objective: Observe the efficacy and safety of Anshen Dingxin Decoction in the treatment of patients with chronic insomnia with heart and spleen deficiency.Methods:Using a randomized control method,72 patients with heart and spleen deficiency chronic insomnia who met the criteria were divided into two groups,with 36 cases each.The treatment group took calming decoction 3 times a day,1 dose a day for 14 consecutive days.The control group took ezolim tablets according to the requirements of 1mg each time and once a day,and took them for 14 consecutive days.And compare the curative effect of PSQI points before and after treatment of the two groups,the curative effect of traditional Chinese medicine syndrome,sleep data,HPA axis-related stress hormone levels,the curative effect of PSQI points of the two groups after follow-up,the curative effect of traditional Chinese medicine syndrome points,and the adverse reactions after treatment.Results:1.Both groups of treatment plans can improve the PSQI score,and the PSQI effect of the treatment group is better than that of the control group(P<0.05)2.The single symptom score of traditional Chinese medicine can be reduced in both groups of treatment plans(P<0.05),and the curative effect of TCM syndrome in the treatment group is better than that of the control group,and the difference is statistically significant(P<0.05).3.Both groups of treatment plans can significantly prolong the deep sleep period,shallow sleep period,REM period and total sleep duration,and reduce the waking time(P<0.001).There is no significant difference between the treatment group and the control group(P>0.05).4.The serum ACTH and COR water of the two groups of patients before and after treatment decreased significantly on average,and there was a significant difference(P<0.001).The reduction in the treatment group was more obvious,and the difference was statistically significant(P<0.05).5.After the treatment,the follow-up was observed for 2 weeks.After 2 weeks,the PSQI scale and the TCM syndrome scale were filled in and recorded again.It was found that the total efficiency of both groups had decreased,but the maintenance rate of the treatment group was higher than that of the control group.Conclusion:1.Anshen Dingxin Decoction is better than asazolam in lowering PSQI points and lowering TCM syndrome points.2.Both Anshen Dingxin Decoction and Asazolam can prolong the patient’s deep sleep period,shallow sleep period,REM and total sleep time,and reduce the patient’s waking time.There is no significant difference between the two.3.Both Anshen Dingxin Decoction and Asazolam have a regulatory effect on serum ACTH and COR levels,and the effect of Anshen Dingxin Decoction is better than that of Asazolam.4.Two weeks after the end of treatment,Anshen Dingxin Decoction and Eszazolam are still effective for patients with heart and spleen deficiency insomnia,and the short-term follow-up continuous effect is better than Eszazolam.5.Anshen Dingxin Decoction is safe and effective in treating chronic insomnia with deficiency of heart and spleen.It can be studied in depth,expanded observation,and laid a certain foundation for clinical promotion and use.