| Objective:To survey the clinical utilization of adding flavor sparing and tonifying and tranquilizing soup in the treatment of tumor-associated insomnia,which is liver-depression and spleen-deficiency form,consisting of the clinical efficacy results as well as the degree of safety,so as to provide new ideas and methods for clinical Chinese medicine treatment of tumor-associated insomnia.Methods:From December 2021 to December 2022,72 patients with liver-depression and spleen-deficiency type CRI who were eligible for the protocol were included in the outpatient or inpatient treatment at the Department of Oncology,Yunnan Provincial Hospital of Traditional Chinese Medicine(The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine);72 patients were randomly divided into control and treatment groups,36 patients in each group;the control group was the one who gave patients eszopiclone tablets to be swallowed on the basis of conventional treatment;the The treatment group was the one who added the treatment of sparing and tranquilizing soup to the treatment of the control group,and the length of treatment was 14 days in both groups;the PSQI score,Chinese medicine evidence score,SAS,KPS score and safety observation index were evaluated in both groups before and after 7 days of the test.Statistics were analyzed with SPSS 26.0.Results:1.Before medical treatment,there was no significant difference between the two teams as far as gender,age,weight,tumor stage,tumor type and other basic conditions are concerned(P>0.05),and the two teams had comparable nature.2.Analysis of the efficacy of insomnia: In terms of overall efficacy,the overall response rate of insomnia treatment was 76.67% in the control team and 93.75% in the treatment team,and there was a significant difference between the two teams(P < 0.05);in the field of the classification of insomnia,there was a meaningful difference between the two teams before and after medical treatment and between the control and treatment teams after medical treatment,and the difference was verified to be significant statistically(P < 0.05).In terms of PSQI scores,each PSQI score showed a decline before and after medical treatment in both teams,and the difference was statistically proved to be significant(P <0.05).In the parts of sleep quality,time to fall asleep,sleep duration and sleep efficiency,the degree of score reduction was higher in the treatment team than in the control team,and the difference was found to be significant after statistical verification(P < 0.05);and the total PSQI scores before and after medical treatment showed a decreasing trend in both groups,with better score reduction in the treatment group(P < 0.05).3.Chinese medicine evidence points: in terms of intra-group comparison between the two teams,it was a meaningful difference between the two teams before and after treatment(P< 0.05),and it was a meaningful difference between the control team and the treatment team after treatment,and the treatment team had better score reduction than the control team(P < 0.05),and the effective rate of improvement of Chinese medicine evidence points was 10.00% and 81.25% in the control team and the treatment team respectively,and the difference was found to be meaningful after statistical verification(P <0.05).4.Self-assessment scale of anxiety: there was a significant intra-group difference in SAS scores between the two teams before and after treatment(P < 0.05);there was a meaningful difference in SAS scores between the two teams after treatment(P < 0.05),and the treatment team reduced more points than the control team,and the difference was meaningful(P < 0.05).5.KPS score: There was no meaningful difference between the control team before and after treatment(P>0.05);compared with the treatment team before and after treatment,there was a meaningful difference between the two(P<0.05),and the KPS score had increased momentum after treatment.6.Adverse reactions: 3 cases of dizziness in the control team and 1 case of diarrhea in the treatment team,the difference between the two teams was not meaningful and not statistically significant(P>0.05).Conclusion:1.The treatment of CRI patients with liver-depression and spleen-deficiency type by adding flavour sparing and toning to tranquilize the mind can enhance the therapeutic effect of clinical insomnia,which is conducive to improving sleep quality,reducing the time to fall asleep,prolonging the length of sleep and increasing sleep efficiency.2.Adding flavour sparing and toning to tranquilize the mind has the function of dredging the liver and strengthening the spleen,anti-cancer and tranquilizing the mind;it has certain efficacy in addressing the improvement of Chinese medicine symptoms in CRI patients with liver-depression and spleen-deficiency type.3.Adding flavour sparing and toning to tranquilize the mind helps alleviate patients’ anxiety and improve their quality of life,and the happenings of adverse effects after application is few. |
PDF Full Text Request