Effect Of Qinggan Powder Acupoint Application Combined With Lercanidipine On The Efficacy And Pulse Wave Velocity Of Primary Hypertension With Hyperactivity Of Liver Yang

Objective:In this study,through a randomized controlled trial,Qinggan Powder acupoint application combined with lercanidipine was used to treat patients with hyperactivity of liver yang primary hypertension,to observe the clinical effect and safety of Qinggan Powder combined with lercanidipine in reducing blood pressure and pulse wave conduction velocity in hypertension patients were observed,providing a new TCM treatment means for the treatment of hypertension patients with arteriosclerosis.Methods:A total of 80 patients who met the inclusion criteria were divided into control group and experimental group with 40 patients in each group according to random number table method.The control group was given health education and lercanidipine tablets,10mg/time,once a day.The experimental group received health education+lercanidipine tablets+Qinggan Powder applied to Yongquan point on both sides.The treatment course was 8 weeks.24 h ambulatory blood pressure monitoring,baPWV determination and TCM syndrome score were performed in both groups before and after treatment,and blood pressure was measured once a day during treatment.SPSS23.0 software was used for statistical analysis of the data,and the changes of the two groups of patients before and after treatment were compared.Results:1.Before treatment,there was no statistical difference in daily blood pressure and 24 h ambulatory blood pressure between the two groups(P>0.05),which was comparable;After treatment,there were statistically significant differences in daily blood pressure and 24 h ambulatory blood pressure between the two groups(P<0.05),indicating that both groups had good antihypertensive effect.After treatment,the blood pressure compliance rates of the experimental group and the control group were 91.89% and 73.68%,respectively,and there was a statistical difference between the two groups(P<0.05).In addition,the daily blood pressure,24 h ambulatory blood pressure and 24 h ambulatory blood pressure reduction rate of experimental group were statistically different from that of control group(P<0.05),indicating that the antihypertensive effect of experimental group was better than that of control group.2.After treatment,the decrease rate of brachial and ankle pulse wave velocity was compared between the two groups,and there was statistical difference(P<0.05).3.Before treatment,there was no statistical difference in TCM syndrome scores in groups(P>0.05),which was comparable.After treatment,there were statistical differences between the control group on vertigo,headache,irritable,facial redness,eyes redness,bitter mouth,dry mouth,deutzia and total syndrome scores compared with before treatment(P<0.05).The scores of each single syndrome and total syndrome in experimental group were statistical differences from those before treatment(P<0.05),the results showd that the treatment schemes in groups could improve symptoms.After treatment,the effective rate of TCM syndrome in experimental group and control group was 81.08% and 55.26%,statistical difference between the two groups(P<0.05).Compared with the control group,the experimental group had statistical differences in vertigo,irritable,bitter mouth,dry mouth,insomnia and total syndrome scores(P<0.05),indicating that the experimental group was better than the control group in improving TCM syndrome,especially in vertigo,irritable,bitter mouth,dry mouth and insomnia.Conclusion:Qinggan Powder applied at bilateral Yongquan point combined with lercanidipine can significantly improve the antihypertensive effect of patients with hyperactivity of liver yang primary hypertension,reduce the brachial and ankle pulse wave velocity,and improve the TCM syndrome of patients well.