Expression Of Urinary Stone Susceptibility Metabolic Markers In Tibetan Population

Objective: To investigate the relationship between urinary stone formation and blood and urine metabolism in Tibetan population,so as to explore the expression level of stone susceptibility metabolic indexes in Tibetan population,further explore the risk factors for urinary tract stone formation in Tibet,and provide reference for clinical treatment,daily education and prevention of stone formation or recurrence in Tibet.Methods: Patients diagnosed with urinary stones(stone group)and non-stone(control group)in the Department of Urology of Tibet Autonomous Region People’s Hospital were given perfect serum calcium,magnesium,phosphorus,uric acid,etc.and24-hour urine biochemical(urine calcium,urine potassium,uric acid,etc.)after admission.Comparative statistical analysis was carried out by comparing blood and urine related indexes between patients in the stone group and patients in the non-stone group.For stone specimens that have been surgically or spontaneously excreted,the stone composition is analyzed using an infrared spectroscopic stone analyzer.Results: A total of 100 patients with stones were collected,including 94 cases(94%)of upper urinary tract stones: 52 cases(52%)of kidney stones and 42 cases(42%)of ureteral stones;There were 6 cases of lower urinary tract stones(6%),5 cases of bladder stones(5%),and 1 case of urethral stones(1%).There were 68(68%)male patients and 32 female patients(32%).The age range is 10～53 years old,and the average age is 32.86+13.43 years old.Among the 100 stone patients,37 cases,accounting for 37%,and 63 cases with two or more components,accounting for 63%.Among the stone components(mixed stone components were mainly the main stone components),there were 77 cases(77%)of calcium oxalate component stones,9 cases(9%)of uric acid stone components,10 cases(10%)of ammonium magnesium phosphate stones,and phosphorus carbonate stones(4%).The results of 24-hour urine detection in stone patients showed abnormal metabolism in 6 cases(6%),hypercalciuria,3 cases(3%)with hypercalciuria,and 54 cases(54%)with low urine output.Calcium oxalate stones are the most common component in stone analysis,and most stones are mixed.There was no significant difference in blood biochemistry between patients in the stone group and the non-stone group(P>0.05).There were differences in urinary biochemical abnormalities between the stone group and the non-stone group,and the24-hour urine calcium,urinary sodium,urinary phosphorus,and uric acid were higher than those in non-stone patients,and the difference was of statistical significance(P<0.05).24-hour urine sodium.24-hour urine output is a risk factor for stone formation(P<0.05).Conclusion: Oxalate is the main component of urinary stones in Tibetan population,and there are more patients with urinary tract stones in men than in women,and the formation of upper urinary tract stones is more than that of lower urinary tract stones.The formation of urinary tract stones is associated with decreased urine output in 24 hours,high urinary phosphorus,high urinary calcium,and high uric aciduria.It is of certain clinical significance to evaluate the urine metabolism of patients with stones and analyze the stone composition of patients with stones for the treatment of patients with urinary stones and to reduce the recurrence rate of stones.