Analysis Of The Medication Patterns And Network Pharmacology Research Of Professor Zhou Yabin In The Treatment Of Stable Angina Pectoris

Objective:This study uses the Traditional Chinese Medicine Inheritance Assistance Platform 3.0 software to conduct research on Professor Zhou Yabin’s clinical treatment of stable angina pectoris patients with coronary heart disease.It summarizes Professor Zhou Yabin’s medication patterns,conducts network pharmacology analysis on the core formulas,and explores the mechanism of its treatment of stable angina pectoris.Method:1.Collect patient cases of stable angina treated by Professor Zhou Yabin at the outpatient department of Heilongjiang University of Traditional Chinese Medicine from January 2019 to October 2021,and establish an Excel database.Input standardized data into the traditional Chinese medicine inheritance assistance platform for data mining.Through modules such as formula analysis,association rules,and cluster analysis,explore the medication patterns of the mentor in treating stable angina patients,and summarize the mentor’s experience in dialectical medication.2.Screen SAP targets through six major disease databases.Screening the compound components of drugs in the core decoction for treating stable angina patients using the TCMSP database and TCMID database,and predicting drug targets using the SwissTargetPrediction database.Use a String database to construct protein interaction relationships.Conduct GO and KEGG enrichment analysis on core targets through the DAVID platform.Result:1.A total of 204 cases were included in this study,males accounted for 58.33%,females accounted for 41.76%.The age of onset was more than 60 years old,accounting for 53.43%;51 to 60 years old was more,accounting for 26.47%;the disease course was more than 10 years accounted for 40.69%,5-10 years accounted for 3 6.76%.2.Among the 204 prescriptions in this study.In the frequency statistics of tongue phenomenon,the top three are lavender tongue,light red tongue,and dark tongue.The top three occurrences in the frequency of tongue coating are thin white coating,white coating and thick coating.Among the frequency of pulse condition,the top three appearing times are deep and weak pulse,deep and thready pulse,and astringent pulse.There are 178 commonly used medicines,with a total frequency of 4008 times.Astragalus is the most frequently used.The top 10 traditional Chinese medicines are Astragalus,Codonopsis,Pinellia,Licorice,Schisandra,Ophiopogon japonicus,Fushen,Poria cocos,Salvia miltiorrhiza,and Platycodon grandiflorum.The medicinal properties of the drugs used are ranked in order of warm,flat,cold,hot,and cool.The ranking of the five flavors in the use of medicines is sweet,bitter,pungent,sour,and salty.In the statistics of drug meridians,the ranking order is spleen meridian,lung meridian,heart meridian,liver meridian,stomach meridian,kidney meridian,large intestine meridian,gallbladder meridian,bladder meridian,small intestine meridian,triple burner meridian,and pericardium meridian.In terms of drug efficacy statistics,the top 5 types of drugs from high to low are drugs for tonifying deficiency,drugs for promoting blood circulation and removing blood stasis,drugs for resolving phlegm and relieving cough,drugs for calming the nerves,and drugs for diuresis and dampness.3.Among the 204 prescriptions in this study,the top 10 symptoms were chest pain,chest tightness,shortness of breath,fatigue,palpitations,poor sleepiness,spontaneous sweating,fatigue,dark purple complexion,and back pain.The syndrome with the highest frequency was qi deficiency and blood stasis syndrome,with a total of 145 cases,and the remaining syndrome types from more to less were phlegm and blood stasis syndrome,qi and yin deficiency syndrome,cold congealing heart pulse syndrome,heart and kidney yin deficiency syndrome,and qi stagnation Heart card.Symptoms seen in patients with qi deficiency and blood stasis include spontaneous sweating,mental fatigue,dark purple complexion,and poor sleepiness.Patients with qi deficiency and blood stasis were divided into 4 types according to other symptoms:concurrent yang deficiency,concurrent yin deficiency,concurrent phlegm turbidity,and concurrent liver depression.In addition to the main symptoms,combined yang deficiency can be seen as chills,cold limbs,tired body,lazy speech,clear and long urination.Concomitant yin deficiency can be seen night sweats,poor sleepiness,soreness of the waist and knees,dizziness and tinnitus.With turbid phlegm,shortness of breath and excess phlegm can be seen.Concomitant liver depression can be seen hypochondriac distending pain,dry mouth,bitter mouth.4.Drug cluster analysis obtained 5 core combinations of drugs for concurrent diseases:Core combination 1:Astragalus,Codonopsis,Danshen,Corydalis Corydalis,Polygala,Fushen.Core combination 2:Codonopsis pilosula,Astragalus root,Alisma,Pori a cocos,Qumai,Dabupi,cinnamon.Core combination 3:Gansong,Citrus aurantium,Bupleurum,Astragalus,Codonopsis,Corydalis.Core combination 4:Lily,Anemarrhena,Ophiopogon j aponicus,Polygonatum,Suanzaoren,Polygala,Angelica.Core combination 5:Pinelli a,Dannanxing,Ground Beetle,Ophiopogon j aponicus,Platycodon grandiflorum.5.This study screened a total of 697 SAP targets.There are 276 traditional Chinese medicine compounds and 143 3 drug targets.Finally,195 treatment targets and 24 core targets were obtained.A total of 214 GO enrichment analyses were obtained,and the core therapeutic targets play multiple roles in biological processes,molecular functions,and cellular components.KEGG pathway enrichment analysis shows that Yangxin Tang is mainly enriched in signal transduction related signaling pathways,immune related signaling pathways,endocrine related signaling pathways,etc.Conclusion:1.A total of 204 cases were included in this study,and the course of disease was more than 10 years.Spontaneous sweating and mental fatigue are the main symptoms,which are manifestations of deficiency of both Qi and blood.2.The most common syndrome types of SAP patients treated by the mentor are Qi deficiency and blood stasis,and the core prescription used is Yangxin Tang,with Huangqi and Dangshen as the core drugs for tonifying qi.For different concurrent symptoms,a combination of five commonly used drugs is commonly used for treatment,including tonifying qi medicine,nourishing lung medicine,astringent yin medicine,and diuretic and osmotic dampness medicine.3.Yangxin Tang may induce the enrichment of 24 core targets such as PIK3CA,JAK3,STAT3,MAPK1,EGFR on multiple signaling pathways such as PI3K/Akt signaling pathway,JAK/STAT signaling pathway,and MAPK signaling pathway,playing a role in inhibiting inflammatory factors,repairing endothelial dysfunction,and reducing oxidative stress,thus achieving the goal of treating SAP.