Correlation Between Peripheral Blood Eosinophil Percentage And Clinical Characteristics Of Patients With AECOPD

OBJECTIVE: In this study,the clinical characteristics and clinical significance of EOS% in patients with AECOPD were assessed based on different levels of peripheral blood eosinophils(EOS)percentage in patients with chronic obstructive pulmonary disease(COPD)with acute exacerbation(Acute Exacerbation of Chronic Obstructive Pulmonary Disease,AECOPD),comparing basic clinical conditions,hospital outcomes,and the distribution of respiratory pathogen culture strains.METHODS: 354 patients with AECOPD were selected as study subjects,and basic clinical data were collected.The patients were grouped according to the EOS% level at the time of admission,242 in group A(EOS%≤2%),79 in group B(2%<EOS%≤5%)and 32 in group C(EOS%> 5%),and the indices,pulmonary function,steroid hormone use,length of hospitalization,hospital outcome,and pathogenic distribution of the three groups were compared and analyzed.RESULTS: The differences in fever symptoms among the three groups were statistically significant(P < 0.05);the differences in white blood cell count,lymphocyte count,neutrophil count,albumin,CRP,calcitoninogen,IL-6,prothrombin time,and urea nitrogen among the three groups were statistically significant(P<0.05);the differences in hospital costs and whether to transfer to the intensive care unit were statistically significant(P<0.05);there was no statistically significant difference in the timing,dose,and number of days to start inhaled glucocorticoids(P>0.05),while there was a statistically significant difference in whether to use systemic intravenous glucocorticoids and the number of days to use intravenous hormones(P<0.05).Correlation analysis was performed: EOS% had a positive correlation with lymphocyte count and albumin(P<0.05)and a negative correlation with white blood cell count,neutrophil count,prothrombin time,days of intravenous hormone use,CRP,calcitoninogen,IL-6,and hospitalization costs(P<0.05).Conclusion:(1)The peripheral blood EOS% of AECOPD patients had negative correlation with CRP,calcitoninogen,and IL-6,and the inflammatory indexes were more significantly elevated in the EOS%≤2% group,and the rate of bacterial infection was higher,and the sputum culturing results suggested that G-bacteria were predominant,mainly Pseudomonas aeruginosa,Acinetobacter baumannii,and Klebsiella pneumoniae,which provided treatment guidance for AECOPD induced by bacterial infection.(2)AECOPD patients in the high EOS% group had lower rates of systemic hormone use,and shorter days of intravenous hormone use,lower rates of ICU,lower rates of bacterial infections,and lower hospitalization costs compared to patients in the low group,suggesting that patients in the high EOS% group responded better to hormones.(3)Peripheral blood EOS% in AECOPD patients is valuable as a biomarker for guiding the development of glucocorticoid treatment regimens.