Clinical Value Of Eosinophils In Acute Exacerbation Of COPD

Objective: To analyze the clinical value of peripheral blood eosinophils in patients with AECOPD.METHODS: Data of 211 patients admitted to hospital due to acute exacerbation of COPD from January 2019 to January 2020 were retrospectively collected.According to the peripheral blood eosinophilic concentration value at admission,2% and 3% were taken as the cutoff values and divided into groups: group A(EOS%≤2%),group B(3%>EOS%>2%)and group C(EOS%≥3%).Baseline data analysis to compare the crowd characteristics(age,gender,smoking,body mass index(bmi)and complications),related biochemical indicators(white blood cell count,neutral grain percentage and blood eosinophil percentage,PCT/CRP/D2 polymers),treatment related situation(proportion of glucocorticoid,hospitalization days,vein intravenous glucocorticoid use the number of days).RESULTS: Data of 211 patients were collected,including 150 patients in group A(71.1%),22 patients in group B(10.4%),and 39 patients in group C(18.5%).There were 163 males(77.3%)and 48 females(22.7%)with an average age of(73.1±9.1)years.There were no significant differences in baseline data,proportion of intravenous hormone use,number of days of use and length of hospital stay among group A,B and C.In terms of biochemical indexes,leucocyte count,N%(neutrophil percentage),CRP and other infection indexes were remarkable different between group A and group B and C(P<0.05),among which group A was higher than the other two groups.In terms of EOS% stability,group A had the highest EOS% stability(64.0%),group B had the lowest EOS%stability(22.7%),and group C had the lowest EOS% stability(59.0%).The difference between group A and C was statistically significant.Conclusion: In patients with AECOPD,the proportion of high eosinophils is higher and EOS% is highly unstable before and after treatment,regardless of the cut-off value of 2% or 3%.The related infection indexes in the high eosinophil group were significantly lower than those in the low eosinophil group,suggesting that non-infectious factors were more likely to cause the high eosinophil phenotype AECOPD,which has reference significance for the clinical comprehensive management of AECOPD patients.