Preliminary Exploration Of The Physique Type Of Hyperuricemia In Minors And Observation Of The Clinical Efficacy Of Jianpi Lishi Decoc Tion

Objective:The distribution of TCM constitution types and related factors in juvenile HUA patients in this region were preliminarily investigated and studied,and the clinical efficacy of the three TCM physique types with the highest proportion was observed by using the Jianpi Lishi Decoction,so as to conduct preliminary exploration for the treatment of juvenile HUA patients with traditional Chinese medicine.Methods:From January 2022 to January 2023,90 juvenile patients with HUA who were hospitalized in the First Affiliated Hospital of Heilongjiang University of Chinese Medicine underwent informed consent,basic information investigation,classification and determination of TCM constitution,physical examination,and laboratory examination.The collected data were statistically processed to analyze the relationship between the distribution of TCM constitution types and relevant factors in this patient group.For the three types of TCM constitution with the highest proportion,a self-designed Jianpi Lishi Decoction was administered on the basis of general treatment for a period of 4 weeks.Through self control and inter group comparison,the improvement of SUA level and body mass score before and after treatment was compared.Results:1.General information: age: 16 cases aged 10-12 years,accounting for18.39%;35 cases aged from 13 to 15 years,accounting for 40.23%;36 cases(41.38%)aged 16-17 years.Gender: 56 males,accounting for 64.37%,31 females,accounting for 35.63%,with a ratio of 1.75:1.BMI: 4 cases were thin,accounting for 4.60%,41 cases were normal,accounting for 47.13%,33 cases were overweight,accounting for 37.93%,and 9 cases were obese,accounting for 10.34%.Smoking and drinking: 14 cases smoked,accounting for 16.09%,73 cases did not smoke,accounting for 83.91%;26 cases drank alcohol,accounting for 29.89%,and 61 cases did not drink alcohol,accounting for 70.11%.Drinking water and high-fructose drinks: 48 cases drank more water,accounting for 55.17%,39 cases drank less water,accounting for 44.83%;38 cases(43.68%)drank more high-fructose beverages and 49 cases(56.32%)drank less high-fructose beverages.Family history and "three highs" : 49 cases with family history,accounting for56.32%,38 cases without family history,accounting for 43.68%;There were3 cases with hypertension,accounting for 3.45%,and 84 cases without hypertension,accounting for 96.55%;There were 12 cases with hyperlipidemia,accounting for 13.79%,and 75 cases without hyperlipidemia,accounting for 86.21%;There were 3 cases with hyperglycemia,accounting for 3.45%,and 84 cases without hyperglycemia,accounting for 96.55%.2.Physique type distribution: The distribution of physique types in 87 juvenile patients with HUA is as follows: 28 cases of phlegm dampness,24 cases of damp heat,21 cases of qi deficiency,9 cases of calmness,4 cases of yin deficiency,1 case of qi stagnation,0 case of deficiency,0 case of blood stasis,and 0 case of intrinsic quality.The top three are phlegm dampness,damp heat,and qi deficiency.3.The relationship between the main constitution and general data: BMI,TG,TC,and LDL-C were found in the three constitution groups of phlegm dampness,damp heat,and qi deficiency,with differences between the groups(P<0.05).Age,blood pressure,HDL-C,and FBG were found in the three constitution groups,with no differences between the groups(P>0.05).Among them,BMI,TG,and TC in phlegm dampness were higher than those in damp heat and qi deficiency,while LDL-C in phlegm dampness was lower than those in damp heat and qi deficiency.Drinking water,high fructose drink intake and hyperlipidemia were significantly different among the three physique groups(P<0.05),and gender,family history,smoking,drinking,hypertension and hyperglycemia were not significantly different among the three physique groups(P>0.05),in which the amount of water for damp heat quality was less than that for phlegm damp quality and qi deficiency quality;The intake of high fructose beverages with phlegm dampness and high blood lipids is more common than that with dampness heat and qi deficiency.4.Relationship between main physique fitness and related influencing factors: BMI,high drinking water and high fructose beverage intake are the risk factors for underage HUA phlegm and wet patients;drinking water is mostly a protective factor for wet and hot patients;LDL-C is a risk factor for patients with air deficiency,and BMI and TC are the protective factors for patients with air deficiency.5.Efficacy: After treatment,the SUA level and body mass fraction of patients in the three groups decreased compared to those in the same group before treatment(P<0.05).The decrease of SUA level in the phlegm dampness constitution group was greater than that in the damp heat and qi deficiency constitution group(P<0.05);The decrease in body mass fracdamp heat and qi deficiency constitution group(P<0.05).tion in the phlegm dampness constitution group was greater than that in the6.Safety comparison: During the treatment period,there were no significant adverse reactions among patients in each physique group.Conclusion:1.Phlegm dampness,damp heat,and qi deficiency are the main physique types of juvenile patients with HUA.BMI,TG,TC,LDL-C,drinking water,consumption of high fructose beverages,and hyperlipidemia are related factors that affect juvenile patients with HUA.2.Reasonable weight control,reduced intake of high fructose beverages,and appropriate drinking water are beneficial for underage HUA patients.3.Jianpi Lishi Decoction can reduce the SUA level and body mass score of juvenile patients with phlegm dampness,damp heat,and qi deficiency constitution.Among them,the improvement of SUA level and body mass score in the phlegm dampness constitution group is more significant than that in the damp heat and qi deficiency constitution group.