The Predictive Value Of MHR For Type 2 Diabetes With Intracranial Artery Stenosis

BackgroundWith the general aging of society and poor lifestyle,the incidence of diabetes has been on the rise,and due to glycolipid metabolism disorders and chronic inflammatory states,patients with type 2 diabetes mellitus(T2DM)are more likely to have microvascular and macrovascular lesions,clinical studies have found that diabetes is an important risk factor for intracranial and extracranial vascular lesions,and after stroke in diabetic patients,their neurological deficit symptoms are more severe and the prognosis is worse,and there is a higher mortality and disability rate.Early clinical intervention in patients with diabetes for intracranial vascular lesions will significantly improve prognosis.The ratio of monocytes to high-density lipoprotein(MHR)is a novel inflammatory index,which has been shown to be associated with coronary artery stenosis,myocardial infarction,ischemic stroke and prognosis in recent years,but studies studying the relationship between MHR and intracranial artery stenosis in patients with T2 DM have rarely been reported,in view of this,this study aims to explore the relationship between MHR and intracranial artery stenosis and related risk factors for T2 DM,aiming to provide a reliable theoretical basis for guiding the treatment and prevention of intracranial artery stenosis.ObjectiveTo explore the relationship between Monocyte to high-density lipoprotein ratio(MHR)and intracranial arterial stenosis(ICAS)in patients with type 2 diabetes patients.MethodsFrom August 2020 to April 2022,297 patients with T2 DM patients affiliated to Fuyang People’s Hospital affiliated to Anhui Medical University were continuously admitted to the CT vascular angiography.According to the results of the CTA test,the patient was divided into two groups: 186 cases of vascular stenosis and 111 cases of 111 cases without vascular stenosis.Calculate the MHR value according to the ratio of the patient’s monocyte to high density lipoprotein.The independent influencing factor of the combination of ICAS patients with a Logistic regression analysis was adopted.The application of the subject(ROC)curve analysis of the subject of the subject(ROC)curve determines whether the T2 DM is the best critical value of the ICAS.Results297 patients in the group,156 men(52.5%),141 cases(47.5%),and 186 cases(62.6%)were combined with ICAS,with an average age(62.47 ± 8.82).There were 111 cases(37.40%)without merging ICAS,and the average age(62.94 ±8.28).The two groups of patients had no statistical differences in gender,age,smoking,BMI,TC,TG,LDL-C,and monocytes(P > 0.05).Compared with the ICAS group,hypertension and coronary heart disease level,glycated hemoglobin(HBA1C),empty blood glucose,monocytes and high-density lipoprotein ratio(MHR)have increased significantly,and HDL levels are significantly reduced.Learning significance(P <0.05).The above data with statistical significance is included in the multi-factor logistic regression model.It is found that MHR,fasting blood glucose,and glycated hemoglobin are independent risk factor for type 2 diabetes with ICAS.HDL is its protection factor.The results of the work characteristics of the subject(ROC)of the subject show that MHR predicts the under area(AUC)of the curve of the T2 DM is0.631,[ 95%confident interval(CI)is 0.567 ～ 0.695,P <0.001],the best interception The point is 3.021,the sensitivity is 61.30%,and the specific degree is 61.40%.ConclusionMHR,fasting blood glucose,and glycated hemoglobin were independent risk factors for type 2 diabetes mellitus and ICAS,and HDL was its protective factor.MHR has a predictive value for T2 DM combined with ICAS.