Correlation Between Monocyte To HDL Cholesterol Ratio And Severity Of Coronary Artery Stenosis

Objective:To investigate the correlation between Monocyte-high density lipoprotein cholesterol ratio and SYNTAX score in the blood of selected patients,and to further explore the relationship between MHR and the severity of coronary artery disease.Methods:the basic date of 352 patients hospitalized in four department of the people’s Hospital of Liaoning Province from August 2018 to September 2019 were analyzed retrospectively,including sex,age,body weight,history of hypertension,and diabetes mellitus,,smoking history,family history of coronary heart disease,and blood biochemical examination under fasting condition,,including blood routine,blood lipid,blood glucose,C-reactive protein,liver and kidney function,MHR,was calculate and recorded.,The results of coronary angiography were recorded in each patient.According to the results of coronary angiography,coronary artery lumen diameter ≥ 1.5mm and whether the lumen diameter stenosis was more than 50%were divided into coronary heart disease group(≥ 50%)and non-coronary heart disease group(﹤50%.There were267 cases of coronary heart disease group,162 cases of male and 105 cases of female,85 cases of non-coronary heart disease group,43 cases of male and 42 cases of female.According to the results of coronary angiography,according to the SYNTAX score(www.SYNTAX.com),divided coronary heart disease group into low score ﹤22,middle group 23-32 and high group>33,including 191 patients with low score group,109 males and 82 females,54 patients in middle group,37 males,17females,22 patients with high score and 17 males and 5 females.The expression of monocyte/high density lipoprotein ratio and other blood biochemical indexes and general data in coronary heart disease group and non-coronary heart disease group were analyzed.Independent sample t-test was used to compare the normal distribution between coronary heart disease group and non-coronary heart disease group,and Mann-Whitney rank sum test was used to compare the two groups that did not accord with normal distribution.The expressions of MHR and other blood biochemical indexes and general data in low score group,middle score group and high score group were analyzed.Analysis of variance and chi-square test were used to compare the normal distribution among the three groups,and Kruskal-Wallis rank sum test was used to compare the three groups that did not accord with the normal distribution.Prarson correlation analysis was used to analyze the relevant data satisfying the positive Pacific distribution,Spearman correlation analysis was used to analyze the correlation between MHR and SYNTAX,and multivariate logistic regression analysis was used to analyze the risk factors of coronary heart disease(CHD)by single factor analysis of variance(ANOVA).Draw ROC curve to judge the efficiency of MHR in diagnosing CHD.SPSS25.0software was used to analyze the data.Result:1.The MHR in the non-coronary heart disease group was 0.39 ±0.22 and that in the coronary heart disease group was 0.45 ±0.26.There was significant difference between the two groups.2.MHR in low risk group,middle risk group and high risk group were 0.39 ±0.18,0.54±0.20 and 0.69 ±0.20,respectively.When compared with each other,MHR existed in high risk group > medium risk group > low risk group,and there was significant difference among the three groups(p < 0.001).3.3.Smoking history,diabetes history,hypertension history,systolic blood pressure(SBP),MHR,CRP as independent variables and coronary heart disease(CHD)as dependent variables were analyzed by multivariate Logistic regression analysis.The results showed that MHR was an independent risk factor for coronary heart disease(OR=3.069,95%CI:1.082-8.705,P=0.035),and hypertension history an independent risk factor for coronary heart disease(OR=3.600,95%CI:2.222-5.833,P=0.000).4.spearman correlation analysis showed that there was a significant positivecorrelation between SYNTAX score and MHR,and the correlation coefficient of two variables spearman was 0.201(P < 0.05),that is,the SYNTAX score increased with the increase of MHR.5.The diagnostic value of MHR to CHD was evaluated by drawing the subject working characteristic curve(ROC curve): the area under the curve(AUC)was 0.710(95%CI0.649-0.771).When the critical value of MHR was 0.47,the diagnostic efficiency was the highest,the sensitivity was 74%,and the specificity was 47.1%.Conclusion:1.MHR was positively correlated with SYNTAX score,significantly correlated with the severity of coronary artery disease,and was an independent risk factor for coronary heart disease.2.When MHR > 0.47,the SYNTAX score of patients with coronary heart disease is higher,and MHR,as a rapid,practical,convenient,cost-effective and predictive inflammatory marker of cardiovascular disease,is helpful for clinicians to predict the severity of coronary artery disease in patients with newly diagnosed CHD.