Relationship Between Iodine Nutritional Status Of Pregnant Women And Neonatal Thyroid Stimulating Hormone

ObjectiveTo detect the urinary iodine concentration(UIC)of pregnant women and neonatal thyroid hormone(TSH)levels,to explore the relationship between the two indicators,and to analyze the effect of iodine nutrition of pregnant women with different gestational ages on neonatal thyroid hormone levels.Methods(1)Participants A total of 93 pregnant women were randomly selected from our hospital from November 2018 to April 2022.(2)Research methods① Informed consent was obtained from 93 pregnant women,and their personal information,including gestational age and age,were obtained.Blood tests were carried out,urine samples were collected,and relevant indicators involved in the study were determined,including urinary iodine concentration(UIC),thyroxine(TSH)and other indicators.All pregnant women identified as subjects were followed up and TSH levels were measured for their newborns after delivery.② In this study,93 pregnant women were identified as research objects,and they were divided into three groups according to the gestational age,which were respectively in the first,second and third trimester of pregnancy.The research objects were 26,31 and 36 people respectively.The indexes of TSH,FT4,FT3 and UIC of pregnant women in three groups were detected and compared.③ To observe and compare the relationship between low UIC and normal UIC in different trimesters and the corresponding neonatal TSH.④ Statistical software: SPSS 19.0 was used for statistics and analysis of relevant data.When P<0.05,the difference between groups could be regarded as statistically significant.Results(1)Among the three groups,there was no significant difference in the three indexes of UIC,FT4 and TSH of pregnant women(P>0.05).Compared with the first two groups,the FT3 level of pregnant women in the third trimester decreased significantly(P<0.001).In terms of UIC/UCr index,the higher level was found in the third trimester group.The other two groups were lower(P=0.028).(2)Normal or low UIC in pregnant women did not significantly affect newborn TSH,and there was no significant difference in this respect(P>0.05).Conclusion(1)The phenomenon of iodine deficiency is more prominent in early pregnancy.(2)Iodine deficiency during pregnancy may not affect neonatal TSH levels.