Discussion On Professor Li Xuejun ’s Medication Rule And Experience In The Diagnosis And Treatment Of Chronic Atrophic Gastritis Based On Data Mining Technology

Objective:Traditional Chinese medicine has certain advantages in the treatment of chronic atrophic gastritis(CAG).In this study,data mining technology was used to analyze the medication rules of Professor Li Xuejun in the diagnosis and treatment of CAG patients,and summarize his clinical experience.Methods:We Collected the first medical records of CAG patients who were treated by Professor Li Xuejun in the Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine from January 2022 to December 2022.Combined with the inclusion and exclusion of medical records that meet the research standards,the data were standardized and entered into the Excel 2010 software to establish a database.The frequency statistics,association rules and cluster analysis of medical record data were carried out by using Excel 2010,SPSS Modeler 18.0 and SPSS Statistics 26.0 software.Results:(1)General conditions: A total of 141 medical records of CAG patients were collected.Among them,73 cases(51.8%)were male patients and 68 cases(48.2%)were female patients,with a male-to-female ratio of 1.07%.The age range of the patients ranged from29 to 78 years old,and the average age was about 55 years old.The 50-59 age group had the most patients,with a total of 68 cases,accounting for 48.2%.(2)Medical case data: the frequency of TCM diseases involved in 141 medical records from high to low were stomach ruffian,epigastric pain,pantothenic acid and noise.A total of 42 symptoms appeared.The top ten symptoms were epigastric fullness,belching,dry mouth,pantothenic acid,bitter mouth,insomnia,heartburn,epigastric distension,foreign body sensation and loose stool.There were 4 items of related tongue,the highest frequency was light white tongue,followed by dark tongue,light red,red tongue,6 items of related tongue coating,the highest frequency was thin white fur,followed by thin yellow fur,white fur,yellow greasy fur,yellow fur,white greasy fur;four related pulse,the highest frequency was string pulse,followed by slippery vein,veinlet,sunken pulse.Among the six related syndrome types,the frequency of spleen and stomach weakness was the highest,followed by liver and stomach qi stagnation syndrome,stomach yin deficiency syndrome,liver and stomach stagnation heat syndrome,spleen and stomach damp-heat syndrome,stomach collaterals blood stasis syndrome.(3)Drug analysis: 141 cases of traditional Chinese medicine prescriptions contained 112 traditional Chinese medicines.Drugs with a frequency of more than 50% include:Bupleurum,Pinellia ternata,Hedyotis diffusa,Rhizoma Curcumae,Coix seed,Poria cocos,licorice,Atractylodes macrocephala,Rhizoma Atractylodis,Perilla frutescens,tangerine peel,white peony,sea scabbard,precocious seed,Scutellaria barbata.The attributes of the four qi were mainly warm,cold and mild drugs;the five flavors were bitter,pungent and sweet,and the meridians were mainly spleen,stomach,liver and lung meridians.(4)Association analysis: with the minimum support degree of 50 and the minimum confidence level of 90% as the standard,the highest support degree of the two medicines was Pinellia ternata Bupleurum,zedoary turmeric,Bupleurum and Hedyotis diffusa,and the combination of Coix seed,zedoary turmeric,Hedyotis diffusa and Hedyotis diffusa was the highest.(5)Cluster analysis: four core prescriptions could be obtained by systematic clustering:the first group of drugs: Bupleurum,Rhizoma Corydalis,Radix Paeoniae Alba,Radix Paeoniae Rubra,Poria,Poria God,keel,oyster,licorice.The second group of drugs: green peel,tangerine peel,Fructus Aurantii,perilla stem,lotus stem,puffy scabbard,corrugated fruit,Coptis chinensis,Evodia rutaecarpa,bamboo ru,Pinellia ternata,Magnolia officinalis,Zhejiang Fritillaria,Platycodon grandiflorum,wood butterfly,albizzia flower,albizzia bark,stone see wear.The third group of drugs: Hedyotis diffusa,Scutellaria barbata,Rhizoma Zedoariae,Liu Jinu,Qianzi,Coix seed,Dendrobium,Radix Astragali,Radix Pseudostellariae,Herba Epimedii.The fourth group of drugs: Atractylodes macrocephala,Fangfeng,white cardamom,Amomum villosum,patchouli,millet malt,Jianqu.Conclusion:(1)Professor Li Xuejun believes that the weakness of spleen and stomach is the basic pathogenesis of CAG,which is caused by qi stagnation,blood stasis,food accumulation,dampness and heat and other factors.(2)Professor Li Xuejun’s treatment of CAG is guided by the thought of “leveling and returning to the source”,and the treatment principle is to consolidate the foundation and cultivate the yuan,and to reconcile qi and blood.(3)The third group of prescription obtained by cluster analysis is Professor Li Xuejun’s core prescription for the treatment of CAG,which is the basic prescription for the tutor to treat CAG.The patients with qi stagnation,blood stasis,food accumulation,dampness and heat and other factors in the course of the disease are treated with this prescription.