| Objective:To investigate the difference in the incidence of Helicobacter pylori(Hp)infection between patients with stable chronic obstructive pulmonary disease(COPD)and healthy adults using the 13 C urea breath test(13C-UBT).To investigate the effects of Hp infection on lung function,arterial blood gas indexes,related inflammatory indexes and coagulation function in patients with stable COPD.Methods:A total of 281 stable COPD patients and 1314 healthy patients admitted to the Fourth Affiliated Hospital of Nanchang University from January 2019 to December2022 were collected.A total of 281 COPD patients with stable period and 1314 health examinations who visited the Fourth Affiliated Hospital of Nanchang University between January 2019 and December 2022 were collected.First,health examination subjects were grouped according to age,including 804 patients of> 40 years,and 300 patients were selected as control group randomly sampled by SPSS.Secondly,281 patients with stable COPD period excluded 18 according to the inclusion and exclusion criteria,and a total of 263 patients with stable COPD period were included in the COPD group.The infection of Hp in the control and COPD groups was compared by 13 C urea breath experiment.263 stable COPD patients were divided into Hp positive(n=116)and Hp negative(n=147)for 13 C urea.The following indicators were analyzed and compared between the two groups: general data,smoking index,clinical comorbidities,pulmonary function,arterial blood gas index,inflammatory index and coagulation function.Finally,SPSS25.0 statistical software was applied to evaluate the effect of Hp infection on each indicators.Results:1.A comparative study of 281 patients in the COPD group and 300 patients in the control group found that there was no significant difference in age and sex between the two groups(P>0.05).The Hp infection rate was 44.8% in the COPD group and 35.3% in the control group(P<0.05).2.The Hp-positive group of 263 COPD patients was compared with the Hp-negative group,and there was no significant statistical difference in general data,smoking index and clinical common comorbidities(P> 0.05).2.1.For patients with COPD of different severity,the lung function between the Hp-positive group and the negative group was compared: 34 cases(43.6%)were mild,34(43.6%)were moderate,6(7.7%)were severe,4 cases(5.1%)were extremely severe,56 cases(49.6%)were mild,37(32.7%)were moderate,16(14.2%)were severe,and 4 cases(3.5%)were extremely severe.In the Hp-positive group,COPD patients with mild airflow limitation were significantly lower than the Hp-negative group for one-second FEV 1 / FVC,first-second forced expiration volume FEV 1 and FEV 1% pred(P <0.05),while there was no significant difference in lung function of patients with moderate,severe and extremely severe airflow limitation(P>0.05).2.2.Comparison of inflammatory indexes between the two groups: there were significant differences in C-reactive protein CRP,serum white blood cell count WBC and eosinophils(EOS)between the Hp-positive group and the Hp-negative group(P<0.05);there was no significant significance in the comparison of NLR,PLR and PLT between the two groups(P>0.05).2.3.Comparison of arterial blood gas indexes between the two groups: there were significant differences in the statistical test of arterial blood gas indexes between the 40-positive group and the 75-negative Hp group(P<0.05).2.4.Comparison of coagulation indexes between the two groups: The coagulation-related indexes AT3,D-D,FDP,PT,PTA,INR,APTT,TT and Fbg were analyzed in the Hp positive and Hp negative groups.The results showed no significant difference(P> 0.05).Conclusion:1,patients with COPD have a higher risk of contracting Hp compared with healthy adults.2.Hp infection will reduce the ventilatory function of COPD patients with mild airflow limitation,exacerbate the inflammatory response,and reduce the oxygenation function of COPD patients. |
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