Association Between 216 Patients With Chronic Obstructive Pulmonary Disease And Helicobacter Pylori Infection Based On "Gathering In The Stomach And Affecting The Lung"

Objective: Propensity score matching was used to analyze the association between HP infection and chronic obstructive pulmonary disease based on “Gathering in the Stomach and Affecting the Lung”.Methods: A total of 216 COPD patients hospitalized in the Respiratory Department of Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University from January 2021 to March 2022 were selected and divided into positive group(101 cases)and negative group(115 cases)according to whether they were infected with HP.The baseline data of the two groups were compared,and the propensity score matching method was used to balance the confounding factors between the groups.The lung function,the number of hospitalizations in the last year and related laboratory indicators were compared between the HP positive group and the HP negative group.Finally,the correlation analysis with TCM syndrome types is carried out.Results:There were statistically significant differences between the two groups in ethnic,residence,hypertension,kidney disease,pulmonary tuberculosis,and COPD history(P<0.05),and the above factors were basically balanced between the two groups after propensity score matching(P>0.05).There was no significant difference in FEV1,FEV1%pred,FVC,FVC%Pred,FEV1/FVC before and after matching(P>0.05).After matching,the number of hospitalization in the HP positive group in the past year was higher than that in the control group,and the difference was statistically significant(P=0.019).Laboratory indicators: before matching,CD3 in HP positive group was higher than that in HP negative group(P=0.039).After matching,the difference of CD3 between the two groups was no longer significant.After matching,the absolute value of neutrophils in HP positive group was higher than that in HP negative group(P=0.005).The TCM syndrome types that accounted for a high proportion in COPD patients included sputum turbidity obstructing lung syndrome(58.80%),lung qi deficiency syndrome(8.33%),sputum stasis syndrome(6.48%),sputum heat obstructing lung syndrome(6.02%),etc.No significant correlation was found between HP infection in COPD patients and TCM syndrome types(P>0.05).Conclusion: Whether or not COPD patients are infected with HP does not affect the level of lung function,but it will increase the number of hospitalization of patients.This study reminds us that HP infection has a certain relationship with non-stomach diseases such as COPD,and provides new thinking for the treatment of lung diseases from the perspective of spleen and stomach under the theory of “Gathering in the Stomach and Affecting the Lung”.However,based on the current data,there is no correlation between HP infection and TCM syndrome types in COPD patients.