| Objective:Overweight and obesity may cause metabolic disorders such as type 2 diabetes mellitus(T2DM),dyslipidemia,and uric acid abnormalities,while increasing the risk of cardiovascular and cerebrovascular diseases.In recent years,some studies have shown that overweight and obesity are closely related to Thyroid nodule(TN).Currently,Body mass index(BMI)and Waist circumference(WC)are used to assess overweight or obesity,but these two indicators have certain limitations.So,there are other new indicators that have been proposed for evaluating overweight or obesity,such as ABSI,BAI,LAP,AVI.And there is little research on the relationship between these indexes and TN.In particular,it was less in people with T2DM.Therefore,this study mainly explores the relationship between the new obesity indicators and thyroid nodule in T2DM patients,which is helpful for the prevention and diagnosis of thyroid nodules in T2DM patients.Method:A total of 121 T2DM patients who were inpatients or outpatients at the Department of Endocrinology and metabolism of the First Affiliated Hospital of Nanchang University were selected.General data of the participants were collected including name,age,sex,course of T2DM,hypertension,smoking and alcohol history,previous history,Systolic blood pressure,Diastolic blood pressure,WC,HC,and biochemical parameters such as fasting blood glucose,fasting insulin,albumin,creatinine,uric acid,blood lipid,thyroid function.WHR,MAP,BMI,a body shape index(ABSI),body adiposity index(BAI),lipid accumulation product(LAP),abdominal volume index(AVI),insulin resistance index(HOME-IR),Insulin secretion function index(HOME-β),triglycerides-glucose index(Ty G)was calculated,and thyroid and abdominal color ultrasonic diagnosis were performed.Independent sample t test and nonparametric test were used to analyze the differences of the above indicators between T2DM without thyroid nodules and T2DM with thyroid nodules.Pearson or Spearman association analysis was used to analyze the correlation between the new obesity index and thyroid nodules in T2DM patients.The risk factors of thyroid nodules associated with T2DM were analyzed by logistic regression analysis.Result:(1)121 T2DM patients were included in this study,and the prevalence of thyroid nodules was 76.03%.Compared with T2DM & non-TN group,the proportion of age,male,non-smoking and non-alcohol consumption,duration of diabetes,BMI,WC,and HC were higher,and the differences between the two groups were statistically significant(P<0.05).There were no significant differences in WHR,SBP,DBP,MAP and hypertension between the two groups(P>0.05).(2)Compared with T2DM & non-TN group,FINS,TG,HOME-IR,HOME-β,BAI,LAP and AVI in T2DM & TN group were increased,with statistically significant differences between the two groups(P<0.05).There were no significant differences in FPG,Hb1 Ac,ALB,Cr,UA,TC,HDL-C,LDL-C,FT4,FT4,TSH,TGAB,ABSI,Ty G(P>0.05).(3)Spearman association analysis showed that BMI,WC,HC and LAP,BAI,AVI were positively correlated with thyroid nodules(correlation coefficients were0.338,0.378,0.229,0.325,0.222,0.334,P<0.05).There was no significant correlation between ABSI and thyroid nodules in T2DM patients(correlation coefficients were-0.027,P>0.05).(4)Taking the indicators with differences between groups as independent variables and the presence or absence of thyroid nodules as dependent variables,multivariate logistic regression analysis showed that age,diabetes course(≥10 years),TG,BMI,WC,LAP,BAI,AVI were independent risk factors for thyroid nodule occurrence in T2DM patients(OR was 1.049,7.382,2.372,1.435,1.090,1.041,1.337,1.284,P<0.05).(5)ROC curve analysis on the predictive value of obesity-related indicators showed that the area under the curve of BAI was the largest.Conclusion:(1)In T2DM patients,elderly,male,patients with long course of diabetes,high BMI,WC,HC,TG,FINS,BAI,LAP,AVI,HOME-IR and HOME-β patients had a greater risk of TN.(2)Age,diabetes course,TG,BMI,WC,LAP,BAI,and AVI were independent risk factors for thyroid nodules in patients with T2DM.(3)ROC curve analysis results showed that BAI had a greater ability to predict TN occurrence in T2DM patients than BMI,WC,WHR,LAP,AVI. |
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