Research On TCM Syndromes Of Thyroid Nodules Based On Data Mining

With the rapid development of modern human society and economy,the accelerated pace of life and the rapid increase of work pressure,the proportion of thyroid nodules in the population is also increasing year by year due to various external factors.At present,Western medicine has a single method and a large trauma for the treatment of thyroid nodules,which cannot be widely accepted by patients.However,traditional Chinese medicine has its unique advantages in treating this disease,and it is often treated according to clinical symptoms.Chinese medicine has many external treatment methods such as acupuncture and local external application in the treatment of this disease,all of which have achieved good clinical results.Although syndrome differentiation is the most critical in Chinese medicine treatment,there is no clear study on the distribution characteristics of thyroid nodules syndrome.This study investigated the distribution of thyroid syndrome in patients with thyroid nodules by questionnaire survey,collected TCM syndrome score information,and used the combination of disease and syndrome to explore the syndrome characteristics of thyroid nodules and between the syndromes Correlation law provides new treatment ideas and basis for clinicalObjectives:To study the general characteristics of thyroid nodules,TCM syndrome elements,TCM syndrome types,and to explore the relationship between thyroid nodules syndrome,comorbidity-disease-syndrome and physical and chemical indicators------Correlation,provide reference data for clinical treatment,and enrich the objective basis of TCM syndrome differentiation,thus improving the accuracy of syndrome differentiationMethods:Through questionnaires,general demographic data,current medical history,past history,physical and chemical indicators,and four diagnostic information of Chinese medicine were obtained.Statistical methods:establish a database,apply SPSS25.0 for statistical analysis of data.In general data,the count data is analyzed by chi-square test;the measurement data is analyzed by t test and analysis of variance.P<0.05 was considered as a significant differenceThe statistical methods of cluster analysis and factor analysis were used to explore the correlation between thyroid nodules and syndromes and comorbidities---the association rules were used to explore the distribution of TCM syndromes and physical and chemical indicators---The law of correlation between them.Result:1.In women with thyroid nodules,women are significantly higher than men(60%female,40%male);the age of onset is mainly between 45 and 75 years old,mainly middle-aged and elderly;BMI is not up to standard Most of them are concentrated in the category of overweight and obesity.2.Explore the results of thyroid nodule syndrome distribution by cluster analysis:(1)The syndrome distribution of thyroid nodules is:yin deficiency,qi stagnation,damp heat,qi deficiency,yang deficiency,dampness,blood stasis;the disease position is:spleen,liver,kidney,heart,lung,stomach(2)The distribution of TCM syndromes of thyroid nodules complicated with hyperthyroidism is:qi stagnation,phlegm dampness,blood stasis,disease position:liver,spleen,heart,lung;TCM syndrome distribution of thyroid nodules with hypothyroidism:qi deficiency,qi stagnation,dampness,yin deficiency,disease position:liver,spleen,kidney,lung;thyroid nodules combined with Hashimoto’s disease TCM syndrome distribution:phlegm,qi stagnation,qi deficiency,yin deficiency,damp heat,The disease position is:liver,spleen,heart3.Exploring the results of syndrome elements and evolution of thyroid nodules by factor analysis:(1)The syndrome elements of thyroid nodules are:damp heat,yang deficiency,dampness,blood stasis;the disease involves spleen,liver,kidney,heart(2)The evolution rule of thyroid nodules syndrome elements is:the syndrome elements of thyroid nodules with disease duration≤1 year are:qi stagnation,blood stasis,phlegm,and the disease involves liver,spleen and heart;1<disease course≤The syndrome elements of thyroid nodules for 3 years are:dampness,damp heat and blood stasis,the disease involves spleen,liver and heart;3 the syndrome elements of thyroid nodules with disease duration≤5 years are:qi deficiency and dampness,The disease involves spleen,liver and lung;the syndrome elements of thyroid nodules with a course of>5 years are yang deficiency and yin deficiency,and the disease involves kidney and lung4.Exploring the results of the syndrome combination and syndrome objectivity of thyroid nodules by means of association rules(1)Combination of thyroid nodule syndrome:The combination of syndromes of thyroid nodules is qi deficiency and blood stasis syndrome,qi stagnation and stagnation syndrome,heart yin deficiency syndrome,qi and yin deficiency syndrome,spleen deficiency and dampness syndrome and damp heat Resisting(2)Physical and chemical indicators-the correlation between the symptoms and the syndrome the symptoms of patients with abnormal TPOAb are:stool is sticky,drowsiness,drowsiness,dry mouth,chest tightness,and easy to appear syndrome is phlegm Dampness syndrome and spleen deficiency and dampness syndrome;patients with TG abnormalities are prone to fatigue,chest tightness or good health,generalized sleepiness,abdominal pain,less abdominal distension,dry mouth and sticky,easy to appear syndrome is qi stagnation Deficiency syndrome and spleen deficiency and dampness syndrome;patients with LDL-C abnormalities are prone to symptoms such as:chest tightness or goodness,drowsiness,dryness,thirst,yellow urine,dry stools,and prone to qi stagnation Resisting syndrome and dampness and heat stagnationConclusion:This topic uses cluster analysis,factor analysis and association rules to conduct data mining analysis.It is concluded that the distribution of TCM syndromes in 226 patients with thyroid nodules is more from the perspective of disease distribution and comorbidity.Dimensional mining analysis,and the correlation between some physical and chemical indicators and TCM syndromes provide more research data and ideas for TCM syndromes and regular research,as well as clinical diagnosis and treatment of this disease.Dialectical treatment in the process provides a reference.