| Background:Three years into the coronavirus pandemic,during which variants including Alpha,Beta,Gamma and Delta emerged,the fifth variant,Omicron,was found to escape immunity more easily and has gradually become the dominant strain in many countries around the world,and we are just emerging from the severe impact of the Omicron pandemic.During the epidemic period,more and more children are infected.SARS-CoV-2 not only affects the psychological growth of children,but also threatens the health and life of children.Therefore,understanding and studying the epidemic characteristics of SARS-CoV-2 in children is helpful for the prevention and treatment of COVID-19 infection in children.Objective:The clinical characteristics of Omicron infected children in Changchun were reported,and the effects of age and vaccination on the nucleic acid negative conversion time of Omicron infected children were further analyzed.Methods:The medical history data of 316 Omicron infected children aged 0-14 years who were admitted to Changchun Hepatobiliary Hospital from March 10,2022 to May 1,2022 were collected,and the clinical symptoms,number of vaccine doses and laboratory tests of the children were recorded.According to different age,different sex,nucleic acid before and after negative,respectively compared the differences in laboratory indicators.The effects of age and vaccine on clinical symptoms and nucleic acid negative conversion time were further analyzed.Result:(1)The clinical symptoms of Omicron infection in children were independent of child age and vaccination status;(2)The expressions of leukocytes,neutrophils,lymphocytes,hemoglobin and platelets,ALT,creatinine(P<0.001)and inflammatory index CRP(P=0.014)on admission were statistically different among all age groups;(3)There were no significant differences in leukocytes,platelets,CRP and ALT between boys and girls,but there were significant differences in neutrophils(P=0.032),lymphocytes(P=0.040),hemoglobin(P=0.003),PCT(P=0.044)and creatinine(P=0.009);(4)The results showed that the total number of white blood cells,neutrophils,lymphocytes and platelets before nucleic acid conversion to negative were significantly lower than those after nucleic acid conversion to negative,the difference was statistically significant(P<0.001).In terms of inflammation index,CRP before nucleic acid conversion was significantly higher than that after nucleic acid conversion(P<0.001),and PCT before nucleic acid conversion was significantly higher than that after nucleic acid conversion(P=0.012).The creatinine was higher before negative conversion than after negative conversion,the difference was statistically significant(P=0.004),while the change of ALT was not significant,there was no statistical difference;(5)The age of children(P=0.008)and vaccination status(P=0.010)could affect the time of nucleic acid turning negative.Conclusion:(1)This study showed that most children with Omicron infection had mild clinical symptoms;(2)In children infected with Omicron,the total number of leukocytes,neutrophils,lymphocytes,and platelets were lower than that after negative conversion,while CRP,PCT and creatinine increased;(3)There are some differences in laboratory tests among children with Omicron infection of different ages and genders;(4)In children 0-14 years old,the longest nucleic acid negative conversion time was in less than 1 year old,and the median negative conversion time was 7 days,while the shortest nucleic acid negative conversion time was in 7 to 14 years old,and the median negative conversion time was 5 days;(5)The negative conversion time of nucleic acid was significantly shortened in children who received 2 doses of vaccine compared with those who did not receive vaccine. |
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