Influencing Factors Of Negative Conversion Time Of Nucleic Acid In Patients With Corona Virus Disease Complicated With Cardiovascular Diseases

Background and objective:The novel coronavirus pneumonia(COVID-19)is an acute respiratory infectious disease affecting humans.The main clinical symptoms of COVID-19 are fever,dry cough and fatigue,which may be accompanied by pneumonia imaging changes.COVID-19 patients with underlying cardiovascular diseases are more likely to develop into severe and critical patients,and the negative nucleic acid conversion time is also prolonged.Therefore,this study explores the etiological distribution,clinical characteristics and influencing factors of the duration of negative conversion in patients with COVID-19 complicated with cardiovascular underlying diseases,aiming to provide ideas and evidence for early clinical diagnosis and treatment of patients with COVID-19 complicated with cardiovascular underlying diseases,as well as predicting the duration of nucleic acid negative conversion in such patients.Method: The epidemiological and clinical data of COVID-19 patients with cardiovascular underlying diseases treated in Sanya Central Hospital,Hainan Province from March 1,2020 to March 1,2023 were collected.14 days was used as the boundary for nucleic acid conversion of confirmed patients.The early conversion group was defined as the negative time ≤14 days,and the late conversion group as the negative time > 14 days.Single-factor and multi-factor logistics regression analysis and Spearman correlation analysis were performed for the related factors that might affect the negative conversion time of nucleic acid.Results:1.A total of 95 patients with COVID-19 combined with cardiovascular diseases were included.The nucleic acid conversion time was(19.26±7.32)days,and the conversion time ranged from 9 to 44 days.2.Logistics regression analysis found that age ≥60,time from symptom onset to hospital admission ≥2 days,DD increased,ALB decreased as independent risk factors affecting the length of negative nucleic acid conversion during treatment(p<0.05).3.Spearman correlation analysis found that the duration of negative nucleic acid conversion was significantly positive correlated with DD concentration in blood(rs=0.305,p<0.001).There was a significant negative correlation between ALB and Spearman(rs=-0.339,p<0.001).Conclusion: Patients with COVID-19 complicated with cardiovascular diseases may be older(≥60 years)when seeking medical treatment,delay in treatment(≥7 days from symptom onset to admission),increase in DD,and decrease in ALB,all of which may lead to prolonged negative nucleic acid conversion time during hospitalization.Therefore,such patients should be closely observed and the isolation time should be extended appropriately.