| Objectives To explore the effect of different antihypertensive drugs on blood pressure in different groups of patients with hypertension.Methods A retrospective study was conducted to collect basic information and cardiovascular health data of inpatients in department of cardiology,Hebei General Hospital from January 1 to June 1,2021.300 patients aged 25-99 with hypertension were enrolled and divided into groups according to gender,age and antihypertensive medication.Statistical analysis of different groups of hypertensive patients taking antihypertensive drugs,before and after the control of blood pressure.Results 1 Comparison of general data between single drug and combined drug groups:A total of 300 patients were collected,which were divided into single drug treatment group(21.7%)and combined treatment group(78.3%)according to medication situation.There was statistical significance in the age composition ratio of patients in the two groups(P<0.05),regardless of age,gender,urban and rural areas,and occupation,there were more inpatients receiving combined treatment.There were significant differences in the proportions of hypertension complicated with coronary heart disease,heart failure,chronic kidney disease and peripheral artery disease between the two groups(P<0.05).Hypertension combined with coronary heart disease was the most common(63.0%),and obesity was the most common cardiovascular risk factor for hypertension(25.0%).2Comparison of drug use and utilization rate of various drug models between the elderly and non-elderly groups:In single drug antihypertensive,the proportion of patients taking beta blockers(BB)in the elderly group was lower than that in the non-elderly group,and the difference was statistically significant(P<0.05);The proportion of patients taking BB combined with diuretics in the elderly group was higher than that in the non-elderly group,with statistical significance(P<0.05).There was no significant difference between the two groups in other hypotensive programs(P>0.05).Among 300 patients,the combination of 2drugs accounted for the most(38.6%),and the utilization rate of BB+calcium channel blocker(CCB)was the highest(16.0%).CCB was the most popular single drug,accounting for 10.0%.As for the selection of antihypertensive drugs,the utilization rates of BB and CCB in the two groups were higher than those of other drugs,and the proportion of patients using Angiotensin converting enzyme inhibitors(ACEI)in the elderly group was lower than that in the non-elderly group,and the proportion of patients using diuretics was higher than that in the non-elderly group,The difference was statistically significant(P<0.05).The use of diuretics was significantly less than that of other antihypertensive agents in both elderly and non-elderly groups.3 comparison of the combined use of antihypertensive drugs in patients of different genders and age groups:In terms of age and gender groups,the combined use of antihypertensive drugs accounted for a large proportion.In addition,the older,the higher the utilization rate of combination medication.Combination drugs accounted for the most in 65-74 years old age group,and young people,25-35 years of age,single drug antihypertensive accounted for more than the elderly.Women were more likely than men to use the drug combination.4 Comparison of therapeutic effects of different drug treatment schemes on hypertension in hospital environment:The most commonly used antihypertensive drug combinations were ACEI/angiotensin receptor blocker(ARB)+BB,ACEI/ARB+CCB and BB+CCB,accounting for8.0%,8.0%and 16.0%,respectively.ACEI/ARB+BB+CCB,ACEI/ARB+BB+diuretic triple medication,accounting for 14.7%,8.3%,and ACEI/ARB+BB+CCB+diuretic quadruple medication(8.3%),and systolic and diastolic blood pressure before and after treatment were significantly reduced(~aP<0.05,~bP<0.05).5 Comparison of the distribution of antihypertensive drugs in hypertensive patients treated with monotherapy and combination therapy:Hypertensive patients treated with monotherapy,CCB drugs accounted for the highest proportion(47.6%);BB was used the most(80.4%)in combination therapy;diuretics were rarely used alone,and were generally used in combination with other antihypertensive drugs.6 Comparison of adverse events under different drug regiments:the incidence of angina pectoris was the highest,up to 50.7%,regardless of single drug or combination of two,three and four drugs,followed by cerebral infarction,myocardial infarction,heart failure and arrhythmia.Conclusions 1 The choice of medication for patients with hypertension during hospitalization varies greatly due to their different ages.Non-elderly group tends to single antihypertensive drug,while the elderly group mostly used combined drug therapy.The application of diuretics in elderly patients is obviously more common than that in non-elderly patients,generally combined with other antihypertensive drugs,but the use of diuretics is still obviously insufficient than that of other antihypertensive drugs.2 In patients with hypertension complicated with coronary heart disease,heart failure,diabetes,chronic kidney disease,peripheral artery disease and other basic diseases,the higher the utilization rate of combination medication,and the blood pressure level could reach normal basically.3 CCB has become the most common monotherapy in the treatment of hypertension,while BB has become the most common monotherapy in combination with hypertension.4 The incidence of angina pectoris is the highest in hypertensive adverse cardiovascular events,and the incidence of hypertension combined with coronary heart disease was the most common.Figure 3;Table 4;Reference 145... |
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