Study On The Efficacy Of Different Administration Methods Of Lactulose Combined With PEG-ELS In Bowel Preparation

Objectives To compare the effects of different administration methods of lactulose combined with compound polyethylene glycol electrolyte solution(PEG-ELS)for bowel preparation,and to explore the value and best administration method of lactulose for bowel preparation.Methods From November 2020 to December 2021,selecting 197 patients to finish general electronic colonoscopy at the Affiliated Hospital of North China University of Science and Technology.They were randomly divided into 3 groups.Group A was given2 L of PEG-ELS 6 hours before colonoscopy.Group B added divided doses of lactulose to group A.Group C added a single dose of lactulose to group A.Collecting the basic data and the history of disease of three groups.Collecting the first defecation time,the number of defecation and the last fecal traits after drinking PEG-ELS.Recording BBPS score,entry time and withdrawal time during the colonoscopy.Collecting the adverse reaction and tolerance after preparation.Use SPSS 26.0 to perform statistical analysis on the data.Measurement data were tested for normal distribution and variance homogeneity.The measurement data is expressed as "mean±standard deviation"(?±).Use single factor variance to comparing mean,and multiple comparison with the LSD.The counting data is expressed as the number of case and the composition ratio.Comparison of rate or composition ratio use chisquare test.Multiple comparison with the Bonferroni.P<0.05 was statistically significant for the difference.Results 1 Comparison of BBPS score: the difference of BBBS score of the right half colon and whole colon was statistically significant(P<0.05),by pairwise comparison,the score of right half colon and whole colon in group B and group C were higher than group A,the difference was statistically significant(P<0.05).2 Comparison of the qualified rate of bowel preparation,the difference of qualified rate of bowel preparation was statistically significant(P<0.05),by pairwise comparison,the qualified rate in group B and group C was higher than group A,the difference was statistically significant(P<0.05).3Comparison of adverse reaction: the difference of abdominal distension and abdominal pain were statistically significant(P<0.05),by pairwise comparison,the incidence of abdominal distension and abdominal pain in group A and group C was higher than group B,the difference was statistically significant(P<0.05).The difference of the incidence of nausea,vomiting,fatigue,palpitation and thirst were not statistically significant(P>0.05).4 Comparison of defecation: the difference of the first defecation time,number of defecation and the last fecal traits were not statistically significant(P>0.05).5 Comparison of entry time and withdrawal time: the difference of entry time was statistically significant(P<0.05),by pairwise comparison,the entry time of group A was higher than group B and group C,the difference was statistically significant(P<0.05).The difference of withdrawal time was not statistically significant(P>0.05).6 Comparison of tolerance and retest willingness: the difference of the tolerance was statistically significant(P<0.05),by pairwise comparison,the incidence of intolerable degree in group A and group C was higher than group B,the difference was statistically significant(P<0.05).The difference of retest willingness rate was statistically significant(P<0.05),by pairwise comparison,the retest willingness rate in group B was higher than group A and group C,the difference was statistically significant(P<0.05).7 Analysis of factors affecting the quality of the bowel preparation: the last slag feces(OR=6.792,95%CI: 2.492-18.507,P<0.05)and the number of defecation(OR=0.814,95%CI: 0.683-0.971,P<0.05)both are the influence factor of the quality of the bowel preparation.Conclusions 1 Both the divided and the single administration of lactulose combined with PEG-ELS can equally improve bowel cleaning.2 The divided administration of lactulose combined with PEG-ELS can reduce the incidence of abdominal distension and abdominal pain,improve the tolerance and willingness to retest of bowel preparation.3 The last slag feces has a negative effect for the quality of bowel preparation and increase the number of defecation can improve the quality of bowel preparation.Figure0;Table11;Reference100...