Observation On The Effect Of Three Different Laxatives On Bowel Preparation Of Colonoscopy In Specific Population

Objective:To compare the efficacy,detection rate of polyps,adverse reactions,sleep quality,patient compliance and tolerance of sodium phosphate,polyethylene glycol electrolyte powder and magnesium sulfate in bowel preparation before colonoscopy.Methods:This study included 180 relatively young(18-55 years)healthy outpatients without kidney disease who underwent colonoscopy in the First Affiliated Hospital of Xiamen University from August 2019 to November 2019.The patients were randomly divided into three groups:group A(n=60),group B(n=60)and group C(n=60).Oral sodium phosphate,compound polyethylene glycol electrolyte powder,50%magnesium sulfate respectively.Colonoscopy was scheduled for all patients in the morning,and bowel preparation was carried out with a split-dose regimen.Patients need to complete a questionnaire before colonoscopy to assess their compliance,tolerance,adverse reactions and sleep quality.The endoscopic physician recorded the number of intestinal polyps detected after colonoscopy and used the Boston bowel preparation scale(BBPS)to score the quality of bowel preparation.Results:There was no significant difference in age,sex,BMI,colonoscopy history,constipation history,diabetes history and abdominal operation history among the three groups(P>0.05).①The total BBPS scores of group A,group B and group C were 7.22± 1.32,7.08± 1.39,6.52± 1.46 respectively.Further comparison showed that the bowel preparation quality of group A and group B was better than that of group C(P<0.0167),but there was no difference between group A and group B(P>0.0167).②There was no significant difference in compliance,polyp detection rate and total adverse reaction rate among the three groups(P>0.05).In the classification of adverse reactions,the rate of nausea in group A was lower than that in group C(10.0%vs 28.3%,P=0.011),patients in the group A experienced less abdominal bloating than those in the group B(6.7%vs 23.3%,P=0.011).③The sleep quality of group A was better than that of group B(81.7%vs 56.7%.P=0.003)and group C(81.7%vs 50.0%.P=0.000).④Compared with group B(93.3%vs 80.0%,P=0.000)and group C(93.3%vs 81.7%,P=0.001),group A had the best tolerance.Conclusion:Sodium phosphate and polyethylene glycol electrolyte powder were superior to magnesium sulfate in intestinal cleansing.Sodium phosphate had the best tolerance and sleep quality,which may be a better option for relatively young(age<55 years)healthy patients without kidney disease.