| Objective: The aim of this study was to investigate the effects of Shenxiong Kuanxiong Decoction on the clinical efficacy of TCM treatment of post-percutaneous coronary intervention angina(Qi deficiency and phlegm stasis syndrome),the efficacy of TCM symptoms,cardiac echocardiography(LVID),blood lipids(TC,TG,LDL-C,HDL-C),high-sensitivity C-reactive protein(hs-CRP),nail-fold microcirculation(NM),and the clinical efficacy of Shenxiong Kuanxiong Decoctionin in the treatment of post-percutaneous coronary intervention angina(Qi deficiency and phlegm stasis syndrome),through research to investigate its clinical efficacy and provide invalid prescriptions for patients.Methods: Seventy-two patients divided into two group in a 1:1 ratio.The control group was treated with Aspirin Enteric-Coated Tablets,Clopidogrel Bisulfate Tablets and Atorvastatin Calcium Tablets as regular drugs;In the other group,using western medicine,as the control group,and adding Shenxiong Kuanxiong Decoction,The treatment course of both groups was 4 weeks.In the study,the general data,efficacy results and safety results of the two groups were observed and documented,and draw conclusions.Results: : According to the study,72 subjects should have been included,but 5 cases occurred experimental abscission,and 1 case excluded,resulting in the inclusion of 66 subjects who completed the experiment,33 case in each groups.(1)SAQ scores: The SAQ levels of both groups showed improvement after treatment,and the treatment group comparison was remarkable and statistically significant,P < 0.01.In the inter-group comparison,the treatment group was more effective than the control group in improving AS,TS and DS,P < 0.001;in the two areas of making the improvement in PL and AF at P > 0.05,there did not seem to be any noticeable variation between the groups(2)Efficacy of TCM syndrome: In the treatment group,the symptoms were improved,and the total TCM symptoms points in each group improved,the therapeutic group had a total effective rate of 93.93% and the controls had a totally effectiveness rate of 78.78%,the treatment group was more efficacious than the control group.(3)Echocardiography(LVID): LVID levels decreased in both groups(P<0.001),and the difference was statistically significant when comparing within the two groups(P<0.001).(4)Serum lipids(TC,TG,LDL-C,HDL-C): TC,TG,LDL-C decreased and HDL-C increased in the two groups(P<0.01).In the control group,except for TG(P>0.05),TC,HDL-C(P<0.05),LDL-C,(P<0.01);the results of the two groups showed statistically significant,TG(P<0.001),and TC,LDL-C,HDL-C(P<0.05).(5)hs-CRP: In terms of reducing hs-CRP levels,intra-group comparison showed that the difference between the control group and the treatment group was not significant(P > 0.05,while the difference in hs-CRP in the treatment group(P < 0.01);compared between the two groups regarding the results after treatment,the difference between the two groups in decreasing hs-CRP was statistically significant(P < 0.05).(6)The nail-fold microcirculation(NM)overall points: Within-group comparison showed that the difference between the NM points in the control group was no meaningful variation,(P>0.05);the treatment group was significant and statistically significant(P<0.01);the comparison between two groups revealed a statistically significant difference in NM points(P<0.001).(7)Safety evaluation: No significant adverse reactions were observed in both groups during the study.It may be concluded that the association of Shenxiong Kuanxiong Decoction is safe in the medical therapy of post-percutaneous coronary intervention angina(Qi deficiency and phlegm stasis syndrome).Conclusion: In the CHD patients with post-percutaneous coronary intervention angina(Qi deficiency and phlegm stasis syndrome),Shenxiong Kuanxiong Decoction combining with convention western medicine may effectively be able to make better effects on anginal syndromes and TCM syndrome,improving LVID,blood lipids,hs-CRP,NM points with good safety. |
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