Effects Of 12 Week Wuqinxi Intervention On Executive Function In Patients With Parkinson’s Disease

Objective:Parkinson’s disease(PD)is a neurodegenerative disease.Nearly one-third of PD patients have cognitive impairment in the early stage.Executive dysfunction is the most prominent feature of cognitive impairment in PD patients.Early intervention of executive function can not only improve the prognosis of dementia,but also improve the quality of life of patients.Among the many intervention strategies used to improve executive function,the effect of physical exercise has been gradually confirmed.The purpose of this study is to explore the impact of 12 week Wuqinxi intervention on executive function of PD patients,and to provide reference basis for PD patients in China to choose low-cost and easy exercise intervention methods.Methods:1.Study subjects: 56 community patients with Parkinson’s disease with Hoehn&Yahr stage 1-3 were recruited from the specialist clinic of the third class hospital.The subjects met the inclusion and exclusion criteria.After signing the informed consent,they were randomly divided into Wuqinxi group and stretching group.A total of 51 people participated in the intervention cycle,including 25 in Wuqinxi group and 26 in stretching group.2.Intervention method: the intervention lasted for 12 weeks,and 60 minutes of exercise were selected in the morning of two consecutive days every week.The Wuqinxi group intervened with fitness Qigong · Wuqinxi promoted by the General Administration of sports,with an intensity of 40-60% HRR;In the stretching group,the upper and lower limbs and trunk muscles were stretched to a slight degree of discomfort.3.Outcomes and methods: the two groups of subjects were tested before the intervention(baseline)and after the intervention(12 weeks after the intervention).The primary outcomes were executive function: using flanker task,more odd shifting task and digit span test to test inhibition function,set shifting and updating function respectively;Secondary outcomes: The Montreal Cognitive Assessment Scale(Mo CA),the new Unified Parkinson’s Disease Assessment Scale Part III(MDS-UPDRS III),the Mini-BESTest,the Hamilton Depression Scale(HAMD),the Hamilton Anxiety Scale(HAMA),and the Parkinson’s Disease Quality of Life Questionnaire 39(PDQ-39)were used to assess overall cognitive function,motor function,balance function,emotional state,and quality of life.4.Statistical analysis: use SPSS 25.0 statistical software to analyze the data.Independent sample t-test was used to analyze the differences between groups,paired sample t-test was used to analyze the differences within groups,and two factor repeated measurement analysis of variance was used to analyze the effects of groups and time.P < 0.05 was considered statistically significantResults1.Inhibitory control: After 12 weeks of intervention,the accuracy rate of the Wuqinxi group under the consistent conditions of the Flanker test increased(90.11±8.97→6.70 ± 6.88%),the reaction time under consistent conditions decreased(768.17 ±128.13→660.19 ±249.28)ms,and the accuracy rate under inconsistent conditions increased(88.57±10.89→95.21±7.96%),and the reaction time under inconsistent conditions decreased(821.83 ±141.44 →737.97 ±169.33)(ms).The differences were statistically significant(p<0.05).The difference in indices in the stretching group was not statistically significant(p>0.05).None of the intergroup differences between the two sets of indicators were statistically significant(p>0.05).2.Set shifting: After 12 weeks of intervention,there were no statistically significant differences between the Wuqinxi before and after the Change in the More-Odd Shifting test(p<0.05).The correctness rate of the stretching group decreased without conversion in the More-Odd shifting test(84.53±14.89→79.96±14.11%),and the difference before and after the intervention was statistically significant(p=0.05),and the difference before and after the change of other outcomes was not statistically significant(p>0.05).3.Updating function: After 12 weeks of intervention,the Digit Span score of the Wuqinxi group increased from 10.86 points to 12.44 points,and the difference before and after the intervention was statistically significant(p<0.001);the difference in index change in the stretch group was not statistically significant(p>0.05).4.After 12 weeks of intervention,the Wuqinxi Group’s Mo CA scores increased(26.32±1.87→27.68 ±1.75),HAMA scores decreased(15.96±9.34 →10.40 ±5.60),HAMD scores decreased(16.20±10.79 → 10.56 ±2.82),Mini-BESTest scores decreased(22.88±2.73→23.92±2.86),MDS-UPDRS III score decreased(17.04±12.19→11.76±8.71)and the PDQ-39(26.84±12.34→19.52 ±11.25)(p<0.05).The difference was statistically significant.The difference was statistically significant in the stretching group’s Mo CA scores(25.81±2.10 →26.65 ±2.19),HAMA scores(11.85±8.42 →7.88 ±7.29),HAMD scores(13.50±10.00 →8.23 ±7.58),and PDQ-39 scores decreased(29.35 ± 17.69 → 24.23 ± 14.58).Mini-BESTest and MDS-UPDRS III scores decreased,but the difference was not statistically significant(p>0.05).Conclusion:1.12 weeks of Wuqinxi and stretching exercise can improve the updating function of patients with Parkinson’s disease,and the improvement of Wuqinxi is more obvious than stretching exercise;2.Wuqinxi and stretching exercise can promote the inhibitory function of patients with Parkinson’s disease;Neither movement can improve the set shifting function.