Effects Of Combined Aerobic And Resistance Exercise On Residual Cardiovascular Risk Indicators In Postmenopausal Women With Dyslipidemia

Objective: The aim of the study was to verify the effects of aerobic combined resistance exercise on residual cardiovascular risk indicators in postmenopausal women with dyslipidemia.It provides abundant theoretical and practical basis for exercise to further reduce the incidence of cardiovascular events.Methods: Thirty-six postmenopausal women with dyslipidemia(aged 49-71 years)were divided into control group(CG,n=18)and exercise group(EG,n=18).The EG have performed aerobic combined resistance exercise for 12 weeks: aerobic exercise adopted a form of aerobic.Exercise duration was about 60 minutes each day.Exercise frequency was twice times a week.The exercise intensity was maintained at 55-65%HRmax;Resistance exercise adopted elastic belt resistance exercise.Exercise duration was about 20 minutes each day.Exercise frequency was twice times a week and exercise intensity was moderate.The CG did not participate in exercise,and all subjects maintained their daily lifestyle and eating habits.Body weight,waist circumference,BMI,body fat percentage,total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),lipoprotein A [Lp(a)],small and dense low-density lipoprotein cholesterol(sd LDL),apolipoprotein AI(apo AI),apolipoprotein B(apo B),serum uric acid(SUA),estradiol(E2),lipoprotein lipase(LPL),liver lipase(HL)and cholesterol ester transporter protein(CEPT)in both groups were measured before and after 12 weeks.Results:1.After 12 weeks of exercise intervention,serum E2 level,body weight,BMI,waist circumference and body fat rate were significantly decreased in the exercise group(P<0.01).E2 was significantly decreased in the control group after 12 weeks(P<0.01),while there were no significant improvement in body weight,BMI,waist circumference and body fat rate in the control group(P<0.01).Body weight,BMI,waist circumference and body fat percentage in exercise group were significantly lower than those in control group after 12 weeks(P<0.01).2.After 12 weeks of exercise intervention,serum TC,LDL-C,non-HDL-C,TC/HDL-C ratio,apo B and SUA level in exercise group were significantly decreased(P<0.05),serum Lp(a),sd LDL and HL level were significantly decreased extremely(P<0.01),serum LPL level was significantly increased(P<0.05).There were no significant differences in blood lipid related indexes in the control group after 12 weeks(P>0.05).After 12 weeks,serum TC,LDL-C,Lp(a)and sd LDL level in exercise group were significantly lower than those in control group(P<0.01),serum HL level was significantly lower than that in control group(P<0.05),and serum LPL level was significantly higher than that in control group(P<0.01).3.Correlation analysis showed that serum HL variable was significantly positively correlated with serum TC variable(r=0.538,P=0.026)and serum non-HDL-C variable(r=0.522,P=0.032).Serum LPL variables were not significantly correlated with serum TC variables(r=-0.411,P=0.102)and serum non-HDL-C variables(r=-0.375,P=0.138).Conclusion:1.Aerobic combined with resistance exercise can improve the body shape of postmenopausal women with dyslipidemia.2.Aerobic combined resistance exercise can improve residual cardiovascular risk indicators of TC,LDL-C,Lp(a),non-HDL-C,TC/HDL-C ratio,sd LDL,apo B and SUA in postmenopausal women with dyslipidemia.The improvement effect of TC and nonHDL-C was suggested by influencing HL and LPL.