Effects Of Aerobic Exercise On Atherosclerotic Risk In Postmenopausal Women

Purpose: Studying the effects of aerobic exercise on lipid metabolism,endothelial function and oxidative stress reaction in postmenopausal women,in order to provide scientific theoretical basis for preventing and controling atherosclerosis in postmenopausal women.Methods: The trial included 32 women with natural menopause for more than one year and dyslipidemia.They were randomly divided into the aerobic exercise group and the control group,16 women in each group.Subjects in the aerobic exercise group participated in a 3-months aerobic exercise according to the exercise prescription,while the control group maintained their original lifestyles.Lipid related indicators(TC,TG,HDL-C,LDL-C),endothelial function related indicators(ET,NO),oxidative stress related indicators(Hcy,Caspase-3)and cardiac functional capacity were measured before and after the intervention.Results:(1)The exercise intervention can effectively reduce the level of TC(P<0.01),LDL-C(P<0.05)and TG,increase the level of HDL-C(P<0.01),improve the lipid metabolism of postmenopausal women.(2)The exercise intervention can effectively reduce the level of ET(P<0.01),increase the level of NO(P<0.05),improve the endothelial function of postmenopausal women.(3)To a certain extent,the exercise intervention may delay the increase trend of Hcy and Caspase-3 in postmenopausal women.(4)The exercise intervention can effectively improve the cardiac functional capacity of postmenopausal women(P<0.05).Conclusion: Aerobic exercise has a positive effect on AS risk factors in postmenopausal women.So it can be used as a primary AS prevention for postmenopausal women.