Clinical Study On The Treatment Of Diarrheal Irritable Bowel Syndrome (Spleen-Kidney Yang Deficiency And Liver Depression) By Sini Decoction Combined With Tongxie Yaofang

Objective: In this study,by comparing with conventional drugs(compound lactic acid bacteria capsules),Sini Decoction combined with Tongxiyaofang was used to treat patients with diarrheal irritable bowel syndrome(spleen-kidney Yang deficiency and liver depression),and the improvement degree of TCM symptom score,stool trait score,symptom severity score of irritable bowel syndrome,anxiety score and other indicators were observed.This study aims to assess the effectiveness of Sini Decoction combined with Tongxie Yaofang in the treatment of diarrheal irritable bowel syndrome(spleen-kidney Yang deficiency combined with liver depression)as well as to suggest clinical options.Method: In each group,36 cases were randomly assigned to 72 patients who met the inclusion criteria.The trial was carried out as a randomized controlled procedure.Complex lactic acid bacteria capsules were administered to the control group,while Tongxie Yaofang and Sini Decoction were administered to the treatment group.The total TCM symptom score,TCM single symptom score,changes in the IBS stool characteristics,defecation frequency score,clinical efficacy,IBS symptom severity score(IBS-SSS),and anxiety score in both groups of patients before and after treatment were observed to evaluate clinical efficacy of Sini Decoction combined with Tongxie Yaofang on IBS-D spleen-kidney Yang deficiency and liver depression.Results: Each group had 31 patients in total,and 62 patients finished the trial.(1)Overall curative effect analysis after treatment: a total effective rate of93.55% was achieved in the treatment group with four cured cases,ten effective cases,15 effective cases,and two effective cases.A total effective rate of 61.29% was achieved for the control group,which had one cure,three effective cases,15 effective cases,and 12 ineffective cases.There was a statistically significant difference between the treatment group and the control group in terms of overall efficacy.(P<0.05).(2)Total score analysis of TCM syndromes: Between the two groups,there was no statistically significant difference in the total score of TCM syndromes prior to treatment(P>0.05),which was comparable.According to a statistical difference between the two groups after treatment and before treatment,the overall scores of TCM symptoms decreased(P<0.05),demonstrating that both treatments are effective in enhancing patients’ clinical TCM symptoms.Results of treatment showed a statistically significant difference(P < 0.05)in the treatment group’s overall score from that of the control group.(3)Integral analysis of each single symptom of TCM: Before treatment,there was no statistical difference in the scores of each single symptom between the two groups(P>0.05),which could be compared.There was a noticeable improvement in the scores of each single symptom in the treatment group after treatment(P<0.01).The control group had significant improvement on other single symptoms except for the aspect of cold limbs(P>0.05),which had no statistical difference compared with before treatment.Compared with the two groups after treatment,better efficacy was achieved by the treatment group than by the control group in improving diarrhea,abdominal cold pain,waist and knee pain,cold shape and limbs,and bulging of both sides,except that there was no statistical difference in eating less and eating less(P>0.05).(4)IBS-SSS scale score analysis: Before treatment,there was no statistical difference in IBS-SSS scale score between the two groups(P>0.05),which could be compared.According to a statistical difference(P<0.01),the scores of both groups decreased after treatment compared to those prior to treatment,indicating that both treatments might increase the severity of the patient’s illness.After being treated,significantly more was achieved by the treatment group than by the control group(P<0.05).(5)Bristol stools and defecation frequency integral analysis: Before treatment,there was no statistical difference between Bristol stools and defecation frequency integral(P>0.05).When both groups were treated after treatment,their scores decreased from those they had before(P<0.01),which suggests that the two groups of treatment had an improved effect on stool characteristics and frequency,and this effect was superior to that of the control group(P<0.05).(6)Analysis of self-rating anxiety scale scores: Before therapy,the two groups experienced no statistically significant differences in self-rating anxiety scale scores(P>0.05).Compared to before,the self-rating anxiety scale score of patients in the therapy group decreased from what it had been before(P<0.05),as did the self-rating anxiety scale score of patients in the control group did not show a statistically significant difference before or after treatment(P>0.05),whereas the scores in the two groups varied statistically(P<0.05),demonstrating that Sini Decoction coupled with Tongxie Yaofang has the potential to lessen patient anxiety.No reduction in patient anxiety was observed in compound lactic acid bacteria capsules.Conclusion: Sini Decoction combined with Tongxie Yaofang can effectively improve the TCM symptoms,severity,characteristics,frequency and anxiety state of patients with diarrheal irritable bowel syndrome(spleen-kidney Yang deficiency and liver depression),Which deserves to be used clinically.