Clinical Observation Of Non-alcoholic Steatohepatitis(Sputum And Dampness Internal Resistance) Combined With Acupoint Embedding

Objective:The clinical efficacy and safety of liver lipid-lowering particles combined with acupoint embedding in the treatment of non-alcoholic steatohepatitis(phlegm and dampness internal resistance)were observed,which provided theoretical and practical basis for the treatment of non-alcoholic steatohepatitis in traditional Chinese medicine.Methods:This study collected the first affiliated hospital of Guangxi university of Chinese medicine outpatient or inpatient patients meet the criteria for 90 patients,through randomized controlled study method,90 patients were randomly divided into group A,B,group C,each group of 30 cases,three groups of patients with diet control and aerobic exercise basic treatment,group A to fly bin capsule single drug therapy,group B to add taste thin liver lipid lowering particles,group C with flavor thin liver lipid lowering particles combined acupoint embedding therapy,three groups of treatment course are 12 weeks.Observe and record the three groups of liver function,body mass index,blood lipid,serum blood glucose,liver controlled attenuation parameters(CAP),body fat rate,abdominal B ultrasound,clinical efficacy,TCM syndrome integral index changes,evaluate its clinical efficacy and safety,provide theoretical basis and practical basis for TCM treatment of NASH,and concluded.Results:1.Specifically,age,gender,disease duration,liver function(ALT,AST),blood lipids,TC,TG,LDL-C),body mass index(BMI),serum blood glucose(GLU),liver CAP,body fat rate(BF),and TCM syndrome score(P>0.05),Baseline data are comparable.2.Comparison of liver function: After 12 weeks of treatment,ALT and AST decreased and the treatment was significant(P<0.05).After treatment,ALT,ALT,AST and ALT A and B were statistically significant(P<0.05);after treatment,ALT,AST in Group A and B(P>0.05).3.Comparison of blood lipid: After 12 weeks of treatment,TC,TG,and LDL-C decreased in the three groups,with a significant difference(P<0.05).After treatment,TC,LDL-C in Group C and B were statistically decreased(P<0.05);group A and LDL-C decreased compared with group B(P<0.05);after treatment,group C was statistically significant between TG and A(P<0.05);group A between TG and B(P<0.05);and group C between TG and B(P>0.05).4.Comparison of body mass index: After 12 weeks of treatment,the three BMI groups were significant(P<0.05).BMI between Group C and A was statistically significant(P<0.05);BMI between Group C and B(P<0.05);BMI between Group A and B(P>0.05).5.Comparison of serum blood glucose:After treatment,GLU decreased in the three groups(P<0.05).GLU decreased in group C compared with group A and group B(P<0.05),and GLU between group A and group B(P<0.05).6.Comparison of liver CAP values: After 12 weeks of treatment,the three groups of CAP decreased significantly more than before treatment(P<0.05).CAP in C and A and B were statistically decreased(P<0.05);CAP in A and B(P<0.05).7.Comparison of body fat rate: After 12 weeks of treatment,BF in all three groups decreased significantly more than before treatment(P<0.05).BF between group C and A(P<0.05);BF between A and B(P<0.05);BF between C and B(P>0.05).8.Comparison of TCM syndrome points: After treatment,the points of TCM syndrome decreased compared with the points before treatment,and the difference was significant(P<0.05).Group C vs group A(P<0.05);group C vs group B(P>0.05);group A and group B(P<0.05).9.Comparison of TCM clinical efficacy and abdominal B-ultrasound efficacy: The difference of the three groups of TCM clinical outcomes was statistically significant(P<0.05).The total response rate of TCM in group C was higher than that of group A,statistically significant(P<0.05);the total response rate of group C and group B(P<0.05);and the total response rate of TCM in Group A was compared with group B(P<0.05).Group C abdominal B super total response rate was higher than group A,significant(P<0.05);Group C abdominal B ultrasound total response rate compared with group B(P<0.05);There was no significant difference in group A and group B(P>0.05).Conclusion:1.The combination of flavor and liver lipid-lowering granules has better efficacy than silibin capsule and ALT,AST,TG,TC,LDLC,C,BMI,CAP and BF in the improvement of NASH patients,and can effectively prevent and cure the disease progression of NASH.2.The total clinical efficacy of TCM and abdominal B-ultrasound and total efficiency are higher than those of the capsule group and the group,and the combined with acupoint embedding therapy can effectively improve the symptoms and clinical symptoms of rib pain,chest pain,fatigue and body obesity.In the process of treatment,acupoint line embedding therapy is simple,safe and has little side effects.