Liver Fat Soluble Progress And Clinical Observation Of The Particle Treatment Of Non-alcoholic Steatohepatitis (phlegm Stagnant Heat)

Objective:To observet the linical effect and blight of The Traditional Chineseherb Medicine gan zhi rong particles (GZRP) to non-alcoholic steatohepatitis (NASH), which are belong to tan shi yu re by TCM Bianzheng. To evaluate objectively the validity and security of GZRP in treating NASH, inquiry into its function mechanism, guide its in the clinical application.Methods:The qualified test-acceptors were divided randomly into two groups:the treatment group and the control group. There were 30 Outpatients in each group without significance in sex, age, symptoms pattern between two groups (P>0.05). The treatment group took The Traditional Chinese herb Medicine GZRP(Changchun, China Medical College Hospital Preparation Room, ratified the text: Chinese characters long (96) 1367, coating bag), three time a day. The control group took Dong Bao Gan Tai(DBGT ratified Symbol: Gil-American in 1996, No. 430110.) 3 pains three times a day. The treatment is for three-month.Results:1,The total efficient of the treatment group is 90.0%, of the control group is 76.7%. The total treatment effect of treatment group and is Superior the control group (P<0.05). This indicating the treatment of GZRP is Superior the treatment of DBGT2,After three months treatment, both groups can improve significantly the total integral calculus of symptoms and advertises (P<0.01).And the treated group is significantly better than the control one (P<0.01).3,Both groups can reduce the weight (P<0.05).There is no significant difference on the two groups (P>0.05)4,Both groups can reduce significantly serum transaminase (AST, AST, GGT) and blood lipid (TC,TG)(P<0.05).There is no significant difference on improving liver function, reducing serum total cholesterol (TC) (P<0. 05).But has significant difference on reducing serum triglyceride (TG)( P<0.05 ).5,On lightening the degree of pathological changes of liver reflecting by B type ultrasonic, both groups have significant difference (P<0.05). Compared with the control group, the treated group has a better result (P<0.05).Conclusions:By three months treatment,the clinical effect of GZRP is alitter superior to DBGT, but in improving the total integral calculus of symptoms and advertises, reducing serum triglyceride (TG), reducing weight and lighting the degree of pathological changes of liver reflecting by B type ultrasonic, GZRP is much better than DBGT. Therefore, GZRP is adapt to non-alcoholic steatohepatitis (NASH), which are belong to tan shi yu re by TCM Bianzheng. It can either reduce blood lipid or protect the liver function and reduce serum transaminsase. It has been certified a safe and effective prescription of Chinese herbal medicine by clinic experiment. It deserves the clinical expansion...