| Objective: By comparing the treatment intervention of Xuanfu Daizhe Decoction and Metoclopramide Hydrochloride Injection,observe the effects of Xuanfu Daizhe Decoction on nausea and vomiting grading,TCM syndrome scores,and tumor markers in patients with primary liver cancer after HAIC surgery The improvement effect of indicators such as food and quality of life scores.To explore the therapeutic effect of Xuanfudaizhe Decoction on postoperative vomiting of primary liver cancer by HAIC,and further enrich the therapeutic principles and methods of postoperative vomiting of primary liver cancer,so as to provide objective scientific basis for further popularization and application of Xuanfu Daizhe decoction,a famous TCM prescription.Methods: A total of 64 patients who met the inclusion criteria and developed gastric vomiting syndrome of liver qi after transcranial hepatic arterial infusion chemotherapy in the Department of Hepatology,the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine from February 2021 to February 2022 were collected.According to random number table method,32 cases were divided into control group(metoclopramide hydrochloride injection group)and 32 cases were divided into treatment group(Xuanfudaizhe Decoction +metoclopramide hydrochloride injection group).The course of treatment was 1 week.The changes of nausea and vomiting grade,TCM syndrome score,tumor markers,quality of life score and other therapeutic indexes of the two groups before and after treatment were observed and compared.Blood routine,liver and kidney function,coagulation function,electrolyte and electrocardiogram were used as clinical safety indexes to comprehensively evaluate the effectiveness and safety of Xuanfudai Zhe decoction on postoperative vomiting after HAIC for primary liver cancer(syndrome of liver qi affecting stomach).In this study,SPSS26.0software was used to analyze the research results.Results: 1.64 patients were included in this clinical study,4 cases were shed during the study,and 60 clinical patient data were actually recorded.2.Before treatment,baseline data of age,sex,height,weight,clinical stage,nausea and vomiting grade and TCM syndrome score of the two groups had no statistical difference,and were comparable(p > 0.05).3.Clinical efficacy: The total effective rate was 96.67% in the observation group and 76.66% in the control group,which was significantly higher than that in the control group(p < 0.05).4.Classification of nausea and vomiting: The classification of nausea and vomiting in the control group after receiving metoclopramide hydrochloride injection was lower than that before treatment,and the classification reduction was more obvious in the observation group treated with Xuanfu Daizhe Decoction,and the difference was statistically significant(p < 0.05).5.TCM syndrome scores: 1 week after treatment,compared with before treatment,TCM syndrome scores of both groups decreased significantly,and the observation group receiving Xuanfudaizhe decoction improved more significantly than the control group,the difference was statistically significant(p < 0.05).6.In terms of tumor markers: 1 week after treatment compared with before treatment,AFP values of observation group and control group were evaluated as stable,and the difference was not statistically significant(p > 0.05).7.Quality of life evaluation: After treatment,both groups improved compared with before treatment,and the improvement degree of observation group was more obvious,the difference was statistically significant(p < 0.05).8.Safety index evaluation: Before and after treatment,no significant abnormal changes were observed in liver and kidney function,electrocardiogram and other safety indexes in the two groups,with no statistical significance(p > 0.05).Conclusion: 1.The curative effect of Xuanfu Daizhe Decoction combined with metoclopramide hydrochloride injection in the treatment of postoperative vomiting after primary liver cancer HAIC is significantly better than metoclopramide hydrochloride injection.2.Xuanfu Daizhe decoction can reduce the degree of postoperative nausea and vomiting,reduce the TCM syndrome score and improve the quality of life of patients,without adverse reactions,and the clinical effect is significant. |
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