Study On Medicatian Rules Of Professor Zhou Xiaoling’s Prescription For Compensatory Hepatitis B Cirrhosis Based On Data Mining

Objective: Through the collection of case data of Professor Zhou Xiaoling’s treatment of compensated hepatitis B cirrhosis patients,data mining and analysis were carried out by using V2.5 software,an auxiliary platform for TCM inheritance,to summarize Professor Zhou’s diagnosis and treatment experience and prescription rules,explore potential new treatment methods,and provide reference experience for clinical treatment of hepatitis B cirrhosis.Methods: According to the inclusion and exclusion criteria,medical records of Professor Zhou Xiaoling’s first and second visits in outpatient treatment of compensated hepatitis B cirrhosis were collected from September 2020 to September 2021.The data collected included the names of patients,gender,age,symptoms,signs,tongue and pulse,composition and dosage of traditional Chinese medicine prescriptions,and other non-drug treatments.After standardized processing,the data were input into V2.5 software of TCM inheritance assistance platform.The statistical analysis and data analysis functions of the software were used for data mining,to summarize medication rules and obtain potential new treatments.Results:1.Ninety-six patients with compensated hepatitis B cirrhosis were included in this study.Gender and age statistics showed that there were 62 male patients,accounting for 64.58% of the total number of patients,and 34 female patients,accounting for 35.42% of the total number of patients,mostly aged 50-59 years old.Statistics of frequency of symptoms showed that the top ten were fatigue,hypochondriac pain,dry mouth,exhaustion,poor sleep,abdominal distension,poor appetite,chilliness,cold belching and belching.Tongue and pulse frequency statistics showed that the common tongue are whitish glossy coating of the tongue,red tongue,dark red tongue,white and thin coating of the tongue,light red tongue and dark purple tongue,and the common pulse pattern are small and wiry pulse,pulse unable shen fine,fine and smooth pulse,pulse string,sinking pulse and fine pulse.2.A total of 201 prescriptions of traditional Chinese medicine were included in this study,involving 157 kinds of traditional Chinese medicine,and the cumulative use frequency of traditional Chinese medicine was 3,092 times.Among them,the top 20 Chinese herbs used frequently were honey-fried licorice root,codonopsis pilosula,cassia twig,pseudo-ginseng,turtle shell,angelica sinensis,rhizoma zingiberis,spina date seed,radix bupleuri,scutellaria baicalensis,roasted rhizoma atractylodis macrocephalae,ligusticum wallichii,the root of kudzu vine,aconite,rhizoma coptidis,poria cocos,rhizoma pinelliae preparatum,polygonatum,radix salviae miltiorrhizae,cynomorium songaricum rupr.The main categories of Chinese medicine are herbal medicine for tonifying deficiency,drugs for relieving Exterior Disorder,heat-clearing drugs,interior-warming drug,the sedative drug,hemostatic,blood-activating and stasis-eliminating compound,water-disinhibiting damp-percolating medicinal,qi-regulating drugs and dampness-resolving medicinal.3.According to the statistics of the dosage of traditional Chinese medicine,the largest dosages were codonopsis pilosula,roasted rhizoma atractylodis macrocephalae,aconite,poria,oldenlandia diffusa,corydalis tuber and parched white peony root,all of which were 30 g,while the smallest dosages were rhizoma Coptidis and donkey-hide gelatin,all of which were 1g.The statistical results of the four properties were mainly warm,cold and flat,and the frequency was 1085 times,831 times and 574 times respectively.The statistical results of five tastes were mainly sweetish taste,pungent flavour and bitter taste,with the frequency of 1752,1239 and 1060 respectively.The statistical results of attribution meridian were mainly spleen channel,liver channel,stomach channel and heart channel,and the frequency was 1378 times,1289 times,1117 times and 1071 times respectively.4.Fifty-five commonly used drug pairs were summarized,such as Codonopsis pilosula-cassia twig,pseudo-ginseng-turtle shell,Codonopsis pilosula-spina date seed,Angelica sinensis-cassia twig,cassia twig-rhizoma zingiberis,radix bupleuri-Scutellaria baicalensis,Angelica sinensis-cassia twig-rhizoma zingiberis,etc.To obtain the core ingredients: codonopsis pilosula,cassia twig,pseudo-ginseng,turtle shell,angelica sinensis,rhizoma zingiberis,spina date seed,radix bupleuri,Scutellaria baicalensis.Seven new prescriptions were obtained and included in the analysis: radix aucklandiae,pericarpium citri reticulatae,rhizoma atractylodis,garden burnet,the root of Chinese pulsatilla,and sedum sarmentosum,oriental wormwood,fructus cannabis,abrus herb,and radix ophiopogonis,donkey-hide gelatin,radix rehmanniae recen,fructus evodiae,moutan bark,and codonopsis pilosula,prepared rehmannia root,dogwood,radix astragali,and prepared rehmannia root,dogwood,cassia twig,Chinese yam,and scutellaria baicalensis,radix bupleuri,moutan bark,the root of kudzu vine,monkshood,roasted Rhizoma Atractylodis Macrocephalae,and pseudo-ginseng,turtle shell,plantain herb,ossa draconis.Conclusion: Professor Zhou Xiaoling believes that the compensatory hepatitis B cirrhosis is located in the liver,which is closely related to the spleen and kidney.The origin of the disease are deficient root and excessive superficial,intermingled deficiency and excess.The pathogenesis are the damage of jueyin liver,long illness leads to deficiency of spleen and kidney,qi deficiency and blood stasis.Based on the theory of the Treatise on Febrile Disease’s "syndrome-differentiation of the six meridians”,professor Zhou Xiaoling is good at distinguishing and treating the disease according to " three yin diseases”.Therefore,the basic principles of treatment are regulating and supplementing "three yin",promoting blood circulation and removing blood stasis.The four characteristics of the use of traditional Chinese medicine are warm,cold and flat,the five main tastes are sweetish taste,pungent flavor and bitter taste,and the main meridians of traditional Chinese medicine are spleen,liver and stomach meridians.The commonly used core Chinese medicine are honey-fried licorice root,codonopsis pilosula,cassia twig,pseudo-ginseng,turtle shell,angelica sinensis,rhizoma zingiberis,spina date seed,radix bupleuri,scutellaria baicalensis,roasted rhizoma atractylodis macrocephalae,ligusticum wallichii,the root of kudzu vine,aconite,rhizoma coptidis,poria cocos,rhizoma pinelliae preparatum,polygonatum,radix salviae miltiorrhizae,cynomorium songaricum rupr.Professor Zhou Xiaoling’s medication rules are mainly warm,combination of frigotherapy and pyretotherapy.She pays attention to harmonizing Yin and Yang and taking into account the whole.The main treatment methods are tonifying qi and generating body fluid,nourishing blood and benefiting the liver,warming and tonifying the spleen and kidney and activating blood and dissolving stasis.