| Research background and Objective:Epilepsy is a common disease of the nervous system,and according to Chinese’s statistics that the number of epilepsy patients have exceeded 9 million.Meanwhile,epilepsy is an important cause of disability and death in children.The classification of epilepsy in children is complex,begin childhood epilepsy with centrotemporal spikes(BECTs)is the most common epilepsy syndrome in preschool and school-age children.It’s onset and disease process are age-dependent,and most children gradually lose their clinical symptoms with increasing age,so previous studies believe that the disease has a good prognosis.But,with the development of cognitive neuroscience and the improvement of research methods,an increasing number of studies have found that children with BECTs may be associated with cognitive impairment,according to statistics,about 12%-17% of children with BECTs have language function defects.Language is the necessary survival ability to communicate with the outside world and understand the objective world.Semantic processing is an important part of language,which connects the form of language to the real world that it refers to.Various methods are now used to study language functions,such as the behavioral scale and cognitive test,magnetoencephalogram(MEG),functional magnetic resonance imaging(f MRI)eventrelated potentials(ERPs)and so on,ERPs is electrophysiological changes recorded from scalp electrodes to evoked brain neural cells using average superposition to reflect cognitive processes.This experiment initially explored the characteristics of ERPs of the semantic initiation paradigm across channels "picture-speech" in children with BECTs and normal children,The relationship between the degree of abnormal discharge of BECTs and the ERPs,and characteristics of brain networks in normal children and children with BECTs under semantic conflict.Using ERPs to screen the children with BECTs have language dysfunction,and giving speech rehabilitation therapy as early as possible.Method:The children with BECTs and normal children aged 5-12 years were used as study subjects,the number of subjects in both groups was 40.Using the E-prime stimulus presentation software presented the "picture-speech" semantic initiation paradigm experiment,the pictures of Peabody Picture Vocabulary Test-Revised(PPVT-R)served as priming stimuli,and picture corresponding to the speech of the words as the target stimulus.The EEG data were recorded using the Neurofax EEG-1200 C system,ERPs was processed using MATLAB＿R2017a,analyzed the waveform characteristics of the ERPs and distribution characteristics of the topographic map during the semantic conflict processing.Initially explored the brain network characteristics of children with BECTs under semantic conflict processing.Results:The "picture-speech" semantic initiation paradigm across channel modes can induce conflict waves in children,the bilateral frontal,apical and midline areas were more obvious,and the left hemisphere is predominant,compared with the traditional N400,its incubation period is long and its conflict wave time limit are longer.Children with BECTs who can elicit conflict waves have a longer incubation period compared to normal children,waveform differentiation is suboptimal,but the statistical differences were lacking.Children with BECTs whose NREM(Non-Rapid Eye Movement)stage discharge index exceeded 60% did not introduce significant conflict waves,their language ratings were also relatively low.Conclusion:The visual-auditory cross-channel "picture-speech" semantic initiation paradigm can induce semantic conflict waves in children.The conflict wave latency and time limit were prolonged in children with BECTs.The brain areas of semantic conflict processing are mainly distributed in bilateral frontal,apical and midline areas.The semantic processing of the conflict was more pronounced in the left hemisphere.Children with BECTs can have semantic processing disorders,and ERPs can provide reference value for early diagnosis. |
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