| ObjectiveThe purpose of our research is to evaluate the cognitive function of children with Benign childhood epilepsy with centro-temporal spikes(BECT)and children with centro-temporal spikes(CTS)but without seizures by neuropsychological tests and neuroelectrophysiological methods.We try to explore the characteristics of cognitive function in the two groups of children.We aim to analyze the possible influencing factors of cognitive impairment in children with BECT.We also want to find the mechanism behind the special discharge phenomenon of CTS in EEG from the cognitive point of view.MethodChildren with epileptic discharges in the central temporal region were diagnosed and evaluated by EEG in the pediatric clinic or inpatient department of the first affiliated Hospital of Kunming Medical University.The patients were divided into BECT group and CTS group on the basis of their diagnosis.Normal children matched with the sex,age and education level of their parents in the case group were included as the healthy control group.Chinese revised Wechsler Intelligence scale for Children and event-related potential P300 were used to evaluate the cognitive characteristics of children with BECT and children with CTS,multiple linear regression and binary Logistic regression analysis were used to analyze the cognitive defects and possible influencing factors of children with BECT.Results1 In the intelligence test,there were differences in the comparison of verbal intelligence quotient(VIQ)and verbal comprehension intelligence quotient(VCIQ)among the three groups(P < 0.05).Further comparison showed that the scores of VIQ and VCIQ of children with BECT were lower than those of healthy controls(P <0.05).There was no significant difference between the other two groups.2 In the subtests of intelligence test,there were differences in vocabulary scores and comprehension scores among the three groups(P < 0.05).Further comparison showed that the scores of vocabulary in children with BECT and children with CTS were lower than those in normal group(P < 0.05).The score of comprehension in children with CTS was lower than that in normal control group(P < 0.05),but there was no significant difference between children with BECT and children with CTS.3 In the event-related potentials P300 test,there was significant difference among the three groups(P < 0.05).The latency of P300 in children with BECT and children with CTS were longer than that of normal group(P < 0.05),but no difference between children with BECT and children with CTS.There was significant difference in the amplitude of P300 among the three groups,and the amplitude of children with BECT was lower than the normal group(P < 0.05).There was no significant difference between the other two groups.4 Multiple linear regression analysis of VIQ,VCIQ in children with BECT showed there was a negative linear dependence between the number of seizures to VIQ and VCIQ(P < 0.05).The binary Logistic regression showed age below or equal to 6 years at seizure onset had statistical significance influence on VIQ,VCIQ and the latency of P300 in patient with BECT.Conclusions1 Patients with BECT have language impairment,such as verbal comprehension,verbal fluency,may also be impaired in advanced cognition such as attention and working memory.2 Normal children with centro-temporal spikes but without seizures may have defects in verbal comprehension,verbal fluency,common sense comprehension and advanced cognitive function.3 The degree of language impairment was positively correlated with more seizures in children with BECT.Age below or equal to 6 years at seizure onset is a significant factor predicting worse language disorders and advanced cognitive impairment in children with BECT.4 Patients with BECT may have a common underlying pathological mechanism with normal children which EEG showed CTS but without seizures.The special discharge pattern of CTS may be related to specific cognitive impairments. |
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