| Objective:To evaluate the quality of life of early pregnant women by using Self-rating Anxiety Scale(SAS),Self-rating Depression Scale(SDS)and Quality of Life Assessment Form(SF-36),understand the adverse lifestyles that affect the outcomes of early pregnancy,and analyze the quality of life and oxidative stress factor HIF-1 α,To explore the mechanism of quality of life affecting early pregnancy loss.Method:From September 2021 to May 2022,218 pregnant women(6-11+6 weeks gestation)with normal pregnancy,threatened abortion and abortion of less than 12 weeks were selected from QINGDAO MUNICIPAL Hospital,and basic data were collected and recorded.According to the outcome of early pregnancy,they were included into the standard normal pregnancy group(70 cases),threatened abortion group(70 cases)and abortion group(70 cases).The quality of life and psychology of all pregnant women were evaluated with the Self-Rating Anxiety Scale(SAS),Self-Rating Depression Scale(SDS)and the Quality of Life Assessment Scale(SF-36);peripheral blood hypoxia-inducible factor HIF-1α was measured by immunosorbent assay;blood β-HCG and progesterone were measured by chemiluminescence.Statistical software was applied to analyse the results to conclude that the difference was statistically significant at P<0.05.Result:1.Comparison of basic information: Age and gestational week did not differ significantly(P>0.05).2.Evaluation of serum HIF-1 levels in various groups: serum HIF-1 levels were noticeably higher higher in the miscarriage group than in the normal pregnancy group(22.29 ± 9.80ng/L>15.14 ± 4.73ng/L,P<0.05),and serum HIF-1α levels were higher in the miscarriage group than in the pre-eclampsia(22.29±9.80ng/L>18.21±8.31ng/L,P<0.05).3.Inter-group comparison of SF-36 scores: the total score of SF-36 in the three groups was statistically significant(P<0.05).Among the eight dimensions,the comparison of energy and mental health was statistically significant(P<0.05);The score of emotional function in the abortion group was lower than that in the normal pregnancy group and threatened abortion group,(P<0.05);The differences were not statistically significant when comparing physiological function,physical function,social function,somatic pain and general health status(P>0.05).4.Comparison of SAS and SDS scores between groups: SAS and SDS scores in the miscarriage group were higher than those of the normal pregnancy group and the preeclampsia group,(P<0.05).5.Comparison of positive rates of SAS and SDS among the three groups: the proportion of moderate and severe anxiety in the abortion group was 55.17% and 83.33%respectively,which was significantly higher than that in the threatened abortion group and the normal pregnancy group;The proportion of mild and moderate depression in the abortion group was 36.84% and 52.83% respectively,which was significantly higher than that in the threatened abortion group and the normal pregnancy group(P<0.05).6.Correlation analysis of serum HIF-lα with blood progesterone and β-HCG level: serum HIF-lα Horizontal and β-HCG was negatively correlated with statistical significance(r=-0.197,P<0.01);There was a negative correlation with progesterone,but not statistically significant(r=-0.087,P<0.05).7.Correlation analysis between serum HIF-lα and SAS and SDS scores: serum HIF-l αlevels were positively correlated with SAS scores with statistical significance(r=0.418,P<0.01);serum HIF-lα levels were positively correlated with SDS scores with statistical significance(r=0.272,P<0.01).8.Correlation analysis between serum HIF-lαlevels and SF-36 scores: serum HIF-l αlevels and physical function,emotional function,energy,mental health,and total quality of life scores were negatively correlated with statistical significance(P<0.05);serum HIF-lα levels and general health status,social function,and somatic pain were negatively correlated but not statistically significant(P>0.05);serum HIF-lα levels and physiological function were positively correlated,but not statistically significant(r=0.014,P>0.05).Conclusion1.Decreased maternal quality of life(mainly in physical function,emotional function,energy and mental health)and emotional disorders are risk factors affecting early pregnancy loss.2.Poor maternal quality of life may act on HIF-1 α induced oxidative stress damage pathway,resulting in early pregnancy loss... |
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