Observation On The Curative Effect Of Self-Designed Prescription For Reducing Fat And Lowering Sugar In Treating Dampness-Heat Syndrome Of Obese Type 2 Diabetes Mellitus

Objective:To observe the clinical effect and security of self-designed prescription for reducing fat and lowering sugar on dampness-heat syndrome of obesity type 2 diabetes.Methods:From November 2021 to October 2022,100 obese patients with type 2 diabetes mellitus in the Endocrinology Department and inpatient department of Weifang Hospital of Traditional Chinese Medicine were selected.According to the principle of randomized controlled trial,the selected patients were randomly divided into two groups,50 patients in each group,and given the same diabetes health education,diet and exercise guidance.The control group took metformin hydrochloride tablets 0.5g once,three times a day.Observation group was additionally given the self-designed prescription for reducing fat and lowering sugar,250 ml once,twice a day.The continuous treatment period was 3 months.Before and after treatment,blood glucose index(fasting,2h postprandial blood glucose and glycosylated hemoglobin),blood lipid index(total cholesterol,triglyceride,low density lipoprotein cholesterol and high density lipoprotein cholesterol),obesity index(body weight,body mass index,waist-hip ratio),TCM syndrome score and total response rate were observed.At the same time,the safety indicators(basic vital signs,blood routine,liver and kidney function)before and after treatment were recorded.The experimental data were recorded with WPS and analyzed with SPSS26.0.Results:1.This study finally completed 94 cases,the control group and the observation group dropped 3 cases each.2.After treatment,the clinical symptoms of both groups were improved,the total response rate of the control group was 59.57%,the observation group was 78.72%,the observation group was better than the control group(P<0.01).3.After treatment,the observation group was better than the control group in improving fasting blood glucose,2h postprandial blood glucose and glycosylated hemoglobin(P<0.05).4.After treatment,the observation group was better than the control group in improving total cholesterol and low density lipoprotein cholesterol(P<0.05).In the improvement of triglyceride,the two groups had similar efficacy(P>0.05);There was no significant improvement in high density lipoprotein cholesterol in 2 groups(P>0.05).5.After treatment,the observation group could effectively lose weight(P<0.05),while the control group had some weight loss compared with before treatment,but there was no statistical significance(P>0.05).In terms of improving body mass index,observation group was better than control group(P<0.05).In terms of improving the waist-to-hip ratio,the observation group could effectively reduce the waist-to-hip ratio of men compared with the control group(P<0.05),and could reduce the waist-to-hip ratio of women to a certain extent,but the effect was not significant(P>0.05).6.After treatment,the scores of TCM syndrome in both groups decreased after treatment,and the observation group was better than the control group(P<0.01).7.Before and after treatment,the basic vital signs of the two groups were stable,the blood routine and liver and kidney function values were within the normal range,with no statistical significance(P>0.05),and no allergy or other adverse reactions were found.Conclusion:Prescription for reducing fat and lowering sugar can better improve the TCM syndroms,fasting blood glucose,2h postmortem blood glucose,glycosylated hemoglobin,total cholesterol,low density lipoprotein cholesterol,body weight,body mass index,waist-to-hip ratio of obese type 2 diabetes mellitus,and it is safe and worthy of widespread clinical application and further research.