| Objective:To observe the clinical efficacy of Xiaochaihu Decoction combined with Wuling Powder in the treatment of chronic eczema and its effect on patients’ anxiety and depression,to explore its effectiveness in alleviating skin lesions,relieving itching,improving patients’ quality of life and relieving their anxiety and depression,so as to provide a new idea for clinical treatment of chronic eczema.Methods:A randomized controlled trial was used to divide 86 patients with chronic eczema who met the requirements of this project into 2 groups,each with 43 cases,in which the treatment group received Xiaochaihu Decoction combined with Wuling Powder and the control group received levocetirizine hydrochloride tablets.Both groups were treated with topical application of Qingpeng ointment and hydrocortisone butyrate ointment,together with psycho-cognitive therapy.The patients’ eczema area and severity index(EASI),visual analogue scale(VAS)scores and dermatological life quality index(DLQI)scores were recorded in detail before treatment,2 and 4 weeks after treatment.The scores of self-rating Anxiety Scale(SAS)and Self-rating Depression Scale(SDS)were recorded before and 4 weeks after treatment.The data were processed and analysed using SPSS-27.0 statistical software.The clinical efficacy of Xiaochaihu Decoction combined with Wuling Powder in the treatment of chronic eczema and its effect on patients’ anxiety and depression were evaluated by comparing the efficacy,adverse effects and recurrence rate of the two groups.Result:1.In this study,41 cases were completed in the treatment group and 2cases were shed,while 40 cases were completed in the control group and 3cases were shed.A total of 5 cases were shed in the two groups,with an overall shedding rate of 5.81%.2.Comparison of eczema area and severity: After treatment,the EASI scores showed a downward trend,and the EASI scores in the treatment group were lower.The EASI scores of the two groups were compared within the group and the EASI sores of the two groups at 2 and 4 weeks after treatment were significantly lower than those before treatment(P<0.01).There was a statistcally difference between the two groups after 2 and 4 weeks of treatment(P<0.05).3.Comparison of pruritus: After treatment,the itchiness of patients in both groups was reduced and the VAS scores showed a downward trend,and the VAS scores of both groups were lower than before.The VAS scores in the treatment group were lower and there was a significant difference(P<0.01).There was a difference between the two groups after 2and 4 weeks of treatment(P<0.05).4.Comparison of quality of life: Patients’ DLQI scores in both groups showed a downward trend after treatment,and DLQI scores in the treatment group were significantly lower(P<0.01).When the DLQI scores of the two groups were compared within the group,the DLQI scores of the two groups decreased at 2 and 4 weeks of treatment compared to the previous ones,and there was a significant difference(P<0.01).5.Comparison of anxiety and depression: After 4 weeks of treatment,the SAS scores and SDS scores of the two groups showed a downward trend,and the scores of the treatment group was lower than that of the control group,with a statistically difference(P<0.01).The results of SAS showed that there were still 11 patients with mild anxiety after treatment,including 2 in the treatment group and 9 in the control group,without moderate or severe anxiety.The results of SDS showed that there were still15 patients with depression in the two groups after treatment,including10 patients with mild depression,6 patients in the control group,4patients in the treatment group,and 5 patients in the control group with moderate depression.There was a statistically difference in the positive rate of anxiety and depression between the two groups after treatment(P<0.05).6.Comparison of effective rate: The total effective rate was 90.2% in the treatment group and 77.5% in the control group;the significant rate was 75.6% in the treatment group and 37.5% in the control group.There was a significant difference in the efficacy of the two groups(P<0.01).7.Comparison of safety: There was 1 adverse event in the treatment group,the incidence of adverse events was 2.4%;and there were 3 adverse events in the control group,the incidence of adverse events in the control group was 7.5%,there was no statistical difference in the incidence of adverse events between the two groups(P>0.05).8.Comparison of recurrent rate: 37 cases in the treatment group were followed up,with 1 case of recurrence;31 cases in the control group were followed up,with 7 cases of recurrence.The recurrence rate in the treatment group was lower and the difference was statistically significant(P<0.05).Conclusion:Xiaochaihu Decoction combined with Wuling Powder has a significantly curative effect in the treatment of chronic eczema,which is better than oral Levocetizine Hydrochloride Tablets.It can reduce the area,pruritus and severity of eczema,relieve patients’ anxiety and depression,and improve their quality of life. |
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