| Objective Through the investigation of hyperuricemia patients in the physical examination population,the epidemiological characteristics of local hyperuricemia were preliminarily understood.It also analyzes the physical characteristics of hyperuricemia population by using the dialectical method of TCM constitution,so as to master the susceptible constitution of hyperuricemia,provide ideas and basis for the prevention and treatment of hyperuricemia in clinical practice,and play a role in blocking the progress of local hyperuricemia disease at an early stage.Methods 1.Using the cross-sectional study method,according to the inclusion criteria and exclusion criteria,select the health examination population from January 2021 to December 2021 in the Physical Examination Center of Shaoxing Traditional Chinese Medicine Hospital for investigation,and collect general information,vital signs,life habits and laboratory indicators,including:physical examination personnel,gender,age,and body mass index.Vital signs,including blood pressure.Life habits,including smoking history and drinking history.Biochemical index:liver function indicators(alanine aminotransferase,glutamic oxaloacetic transaminase),renal function indicators(blood urea nitrogen,creatinine,blood uric acid),and other biochemical items(fasting blood glucose,triglycerides,total cholesterol,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol).After collecting data,establish a database and use statistical software for statistics and analysis.To master the distribution of blood uric acid level in hyperuricemia population(different ages,genders,life habits,biochemical indicators);To study the related factors affecting the prevalence of hyperuricemia.2.By means of questionnaire survey,the Constitution Classification and Determination Table of Traditional Chinese Medicine issued by the Chinese Society of Traditional Chinese Medicine in 2009 was used to collect constitution data,and the constitution was determined by referring to nine constitution classification methods of Professor Wang Qi of Beijing University of Traditional Chinese Medicine,so as to master the susceptible constitution and constitution distribution characteristics of hyperuricemia population,and analyze the relationship between constitution and blood uric acid related factors.Results 1.(1)In 2021,the number of physical examinees in Shaoxing Traditional Chinese Medicine Hospital was 4159,the number of hyperuricemia was 425,and the incidence of hyperuricemia was 10.22%.Among 425 patients with hyperuricemia,359(84.47%)were male and 66(15.53%)were female.The ratio of male to female was about 5.4:1.0.(2)The age of all hyperuricemia patients was between 7 and 85 years old,with an average age of(40.09 ± 14.13)years.(3)In general,there are differences in blood uric acid levels between men and women in the hyperuricemic population.The comparison of blood uric acid levels between men’s age groups and women’s age groups shows that P<0.05,which is statistically significant.The general trend of blood uric acid level in male population decreases with age,while that in female population decreases with age before 49 years old,and increases with age after 50 years old.(4)The blood uric acid level of non-smokers and people with different smoking frequencies in the HUA population was found to be statistically significant(P=0.000<0.05).(5)The level of serum uric acid in the HUA population was higher than that in the HUA population with normal indicators in the overweight/obesity group,the low high-density lipoprotein cholesterol group,the high serum creatinine group,and the blood urea nitrogen group(P<0.05).(6)Age,sex,BMI,BUN,CR,HDL-C were correlated with the serum uric acid level in HUA population(P<0.05).(7)The increase of serum creatinine has a significant impact on the level of serum uric acid in the HUA population.2.After informed consent,152 of 425 HUA people were included for physique analysis,152 questionnaires were collected,and 121 questionnaires were finally obtained for physique identification after eliminating the missing items.(1)According to the proportion of the physical distribution in the 121 cases of HUA population collected by the survey,the order is:damp heat quality>phlegm dampness quality>yang deficiency quality>qi deficiency quality>peace quality>blood stasis quality>yin deficiency quality>qi stagnation quality>characteristic quality.(2)The nonparametric test and analysis on the blood uric acid level of three main constitutions of the HUA population,namely,damp heat,phlegm damp and yang deficiency,showed that the P value was 0.621,greater than 0.05,and the difference was not statistically significant.There was no significant difference in serum uric acid levels among the physical groups.(3)The results showed that there were significant differences in the distribution of age and BMI among the three constitution groups(P<0.05).The age of yang deficiency is greater than phlegm dampness and damp heat,and the BMI of phlegm dampness is greater than damp heat and yang deficiency.However,blood pressure,TG,TC,CR,BUN,AST,ALT,FBG,LDL-C and HDL-C had no statistical significance among the three constitution groups.Conclusion 1.The level of blood uric acid in HUA population is correlated with sex,age,BMI,high-density lipoprotein cholesterol and renal function(blood creatinine and blood urea).Blood creatinine is an important influencing factor of blood uric acid level in hyperuricemia.2.In the HUA population,the TCM constitution types are mainly damp heat,phlegm dampness and yang deficiency.Age and BMI are the main factors affecting the constitution of the HUA population.The body mass index of phlegm dampness constitution group is significantly higher than that of the other two groups,so the benefit of phlegm dampness constitution group in controlling uric acid level,adjusting constitution and actively controlling weight can be greater than that of other constitution groups. |
PDF Full Text Request