The Study Of The Related Influencing Factors And TCM Constitution Distribution Of Hyperuricemia Complicated With Overweight/Obesity

ObjectiveTo analyze the differences of related factors and pathological TCM Constitution distribution characteristics of hyperuricemia combined with overweight/obesity,and to provide objective medical basis for early clinical intervention and treatment.MethodsThis study was started after being approved by Guangdong Provincial ethics committee.Using a retrospective cross-sectional survey,2661 subjects who met the inclusion criteria from January 2017 to December 2018 in Ersha physical examination center of Guangdong Provincial Hospital of traditional Chinese medicine were systematically searched.The subjects were divided into H-O group(high uric acid with overweight/obesity group)613 cases,H-N group(high uric acid with normal weight group)368 cases,N-O group(normal uric acid with overweight/obesity group)457 cases,N-N group(normal uric acid with normal weight group)1223 cases according to the diagnostic criteria.ResultsThere were significant differences in age,gender,height,weight,BMI,SBP,DBP,waist circumference,WHtR,complications(kidney stones,gallbladder stones,gallbladder polyps,fatty liver),SCr,ALT,AST,ALB,TC,TG,HDL-C,LDL-C,FBG and other indicators between H-O group and N-N group.After excluding the factors causing multicollinearity,other factors were included in the binary logistic regression analysis.The results showed that gender(female)and HDL-C were protective factors in HO group,while kidney stones,fatty liver,DBP,TG and SCR were risk factors.In terms of TCM Constitution distribution,Fisher’s exact test showed that there was significant difference in TCM Constitution distribution among the four groups(P<0.001).The common constitution of H-O group was phlegm dampness,that of H-N group was damp heat,and that of N-O group was phlegm dampness and Qi deficiency with phlegm dampness.There was significant difference between phlegm dampness constitution and H-O(P<0.001).The OR value was 43.750,which indicated that the incidence of H-O in people with phlegm dampness constitution was 43.750 times of that in people with mild constitution.ConclusionThe coexistence of hyperuricemia and overweight/obesity may aggravate the progress of the disease.Compared with the normal population,hyperuricemia is more likely to have the risk of high blood pressure,dyslipidemia,and decreased renal function.In addition,special attention should be paid to the occurrence of kidney stones and fatty liver.Phlegm dampness constitution is a high-risk constitution type.Regulating phlegm dampness biased constitution can effectively prevent the occurrence of HUA combined with overweight/obesity.